Description: Homo sapiens kinesin family member 13A (KIF13A), transcript variant 4, mRNA. RefSeq Summary (NM_001105568): This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr6:17,759,414-17,987,854 Size: 228,441 Total Exon Count: 38 Strand: - Coding Region Position: hg19 chr6:17,761,088-17,987,694 Size: 226,607 Coding Exon Count: 38
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): KIF13A CDC HuGE Published Literature: KIF13A Positive Disease Associations: height
, Prostatic Neoplasms Related Studies:
height Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15.
[PubMed 18391951]
Prostatic Neoplasms Sha Tao et al. Carcinogenesis 2012, A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants., Carcinogenesis.
[PubMed 22219177]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00225 - Kinesin motor domain PF00498 - FHA domain PF12423 - Kinesin protein 1B PF12473 - Kinesin protein PF16183 - Kinesin-associated PF16796 - Microtubule binding
ModBase Predicted Comparative 3D Structure on Q9H1H9-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP896415 - Sequence 1279 from Patent EP3253886. AJ291579 - Homo sapiens mRNA for KINESIN-13A2 (KIN13A gene). AJ291578 - Homo sapiens mRNA for KINESIN-13A1 (KIN13A gene). AY014403 - Homo sapiens kinesin-like protein RBKIN1 (RBKIN) mRNA, complete cds, alternatively spliced. AY014404 - Homo sapiens kinesin-like protein RBKIN2 (RBKIN) mRNA, complete cds, alternatively spliced. BC127115 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150707 IMAGE:40125246), complete cds. BC127116 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150708 IMAGE:40125251), complete cds. BC001730 - Homo sapiens cDNA clone IMAGE:3353875, containing frame-shift errors. BC023613 - Homo sapiens cDNA clone IMAGE:4646849, containing frame-shift errors. BC062673 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone IMAGE:6654466), with apparent retained intron. AK130742 - Homo sapiens cDNA FLJ27232 fis, clone SYN06360. AK025303 - Homo sapiens cDNA: FLJ21650 fis, clone COL08516. AK225214 - Homo sapiens mRNA for kinesin family member 13A variant, clone: COL08516. JD336425 - Sequence 317449 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H1H9 (Reactome details) participates in the following event(s):
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins