Human Gene KIF13A (uc003ncf.3)
  Description: Homo sapiens kinesin family member 13A (KIF13A), transcript variant 4, mRNA.
RefSeq Summary (NM_001105568): This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Transcript (Including UTRs)
   Position: hg19 chr6:17,759,414-17,987,854 Size: 228,441 Total Exon Count: 38 Strand: -
Coding Region
   Position: hg19 chr6:17,761,088-17,987,694 Size: 226,607 Coding Exon Count: 38 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:17,759,414-17,987,854)mRNA (may differ from genome)Protein (1749 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KIF13A
CDC HuGE Published Literature: KIF13A
Positive Disease Associations: height , Prostatic Neoplasms
Related Studies:
  1. height
    Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15. [PubMed 18391951]
  2. Prostatic Neoplasms
    Sha Tao et al. Carcinogenesis 2012, A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants., Carcinogenesis. [PubMed 22219177]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.49 RPKM in Artery - Coronary
Total median expression: 340.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.60160-0.635 Picture PostScript Text
3' UTR -499.101674-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00225 - Kinesin motor domain
PF00498 - FHA domain
PF12423 - Kinesin protein 1B
PF12473 - Kinesin protein
PF16183 - Kinesin-associated
PF16796 - Microtubule binding

SCOP Domains:
49879 - SMAD/FHA domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9H1H9-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LP896415 - Sequence 1279 from Patent EP3253886.
AJ291579 - Homo sapiens mRNA for KINESIN-13A2 (KIN13A gene).
AJ291578 - Homo sapiens mRNA for KINESIN-13A1 (KIN13A gene).
AY014403 - Homo sapiens kinesin-like protein RBKIN1 (RBKIN) mRNA, complete cds, alternatively spliced.
AY014404 - Homo sapiens kinesin-like protein RBKIN2 (RBKIN) mRNA, complete cds, alternatively spliced.
BC127115 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150707 IMAGE:40125246), complete cds.
BC127116 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150708 IMAGE:40125251), complete cds.
BC001730 - Homo sapiens cDNA clone IMAGE:3353875, containing frame-shift errors.
BC023613 - Homo sapiens cDNA clone IMAGE:4646849, containing frame-shift errors.
BC062673 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone IMAGE:6654466), with apparent retained intron.
AK130742 - Homo sapiens cDNA FLJ27232 fis, clone SYN06360.
AK025303 - Homo sapiens cDNA: FLJ21650 fis, clone COL08516.
AK225214 - Homo sapiens mRNA for kinesin family member 13A variant, clone: COL08516.
JD336425 - Sequence 317449 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H1H9 (Reactome details) participates in the following event(s):

R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001105568, NP_001099038, Q9H1H9-3, RBKIN
UCSC ID: uc003ncf.3
RefSeq Accession: NM_001105568
Protein: Q9H1H9-3, splice isoform of Q9H1H9 CCDS: CCDS47381.1, CCDS54967.1, CCDS54968.1, CCDS47380.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001105568.2
exon count: 38CDS single in 3' UTR: no RNA size: 7101
ORF size: 5250CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 10598.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.