Human Gene RPP21 (uc003nqf.2)
Description: Homo sapiens ribonuclease P/MRP 21kDa subunit (RPP21), transcript variant 3, mRNA.
RefSeq Summary (NM_001199121): RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009].
Transcript (Including UTRs)
Position: hg19 chr6:30,312,906-30,314,635 Size: 1,730 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr6:30,312,949-30,314,550 Size: 1,602 Coding Exon Count: 5
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RPP21
CDC HuGE Published Literature: RPP21
Positive Disease Associations: Body Height
Related Studies: Body Height , , .
[PubMed 0 ]
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF04032 - RNAse P Rpr2/Rpp21/SNM1 subunit domain
ModBase Predicted Comparative 3D Structure on Q9H633-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
EU012025 - Homo sapiens TRIM39-like protein (TRIM39R) mRNA, partial cds.LF210820 - JP 2014500723-A/18323: Polycomb-Associated Non-Coding RNAs.AF212152 - Homo sapiens ribonuclease P subunit (RPP21) mRNA, complete cds.AJ504714 - Homo sapiens mRNA for ribonucleoprotein V2 (CAT60-V2 gene).AK026291 - Homo sapiens cDNA: FLJ22638 fis, clone HSI06727.BC011730 - Homo sapiens ribonuclease P/MRP 21kDa subunit, mRNA (cDNA clone MGC:19462 IMAGE:4422871), complete cds.AJ504715 - Homo sapiens mRNA for ribonucleoprotein V3 (CAT60-V3 gene).AJ504713 - Homo sapiens mRNA for ribonucleoprotein V1 (CAT60-V1 gene).AJ504716 - Homo sapiens mRNA for ribonucleoprotein V4 (CAT60-V4 gene).CU680032 - Synthetic construct Homo sapiens gateway clone IMAGE:100020626 5' read RPP21 mRNA.HQ448318 - Synthetic construct Homo sapiens clone IMAGE:100071734; CCSB006968_01 ribonuclease P/MRP 21kDa subunit (RPP21) gene, encodes complete protein.KJ899585 - Synthetic construct Homo sapiens clone ccsbBroadEn_08979 RPP21 gene, encodes complete protein.LF341369 - JP 2014500723-A/148872: Polycomb-Associated Non-Coding RNAs.LF341368 - JP 2014500723-A/148871: Polycomb-Associated Non-Coding RNAs.JD282687 - Sequence 263711 from Patent EP1572962.MA446397 - JP 2018138019-A/18323: Polycomb-Associated Non-Coding RNAs.MA576946 - JP 2018138019-A/148872: Polycomb-Associated Non-Coding RNAs.MA576945 - JP 2018138019-A/148871: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: C6orf135, CAT60, NM_001199121, NP_001186050, Q9H633-3UCSC ID: uc003nqf.2RefSeq Accession: NM_001199121
Protein: Q9H633-3 , splice isoform of Q9H633
CCDS: CCDS56410.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001199121.1
exon count:
5 CDS single in 3' UTR:
no
RNA size:
568
ORF size:
435 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
1070.00 frame shift in genome:
no
% Coverage:
99.12
has start codon:
yes
stop codon in genome:
no
# of Alignments:
7
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.