Human Gene ATAT1 (uc003nqv.3)
  Description: Homo sapiens alpha tubulin acetyltransferase 1 (ATAT1), transcript variant 1, mRNA.
RefSeq Summary (NM_001031722): This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Transcript (Including UTRs)
   Position: hg19 chr6:30,594,663-30,614,598 Size: 19,936 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr6:30,594,981-30,614,420 Size: 19,440 Coding Exon Count: 13 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:30,594,663-30,614,598)mRNA (may differ from genome)Protein (409 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIOMIMPubMedReactomeTreefamUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ATAT1
Diseases sorted by gene-association score: blood coagulation disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.50 RPKM in Pituitary
Total median expression: 349.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.30318-0.341 Picture PostScript Text
3' UTR -18.57178-0.104 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF05301 - GNAT acetyltransferase, Mec-17

ModBase Predicted Comparative 3D Structure on Q5SQI0-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC006105 - Homo sapiens chromosome 6 open reading frame 134, mRNA (cDNA clone MGC:12938 IMAGE:2820493), complete cds.
LF210811 - JP 2014500723-A/18314: Polycomb-Associated Non-Coding RNAs.
AK023220 - Homo sapiens cDNA FLJ13158 fis, clone NT2RP3003552.
AK298743 - Homo sapiens cDNA FLJ60791 complete cds.
AK225107 - Homo sapiens mRNA for Hypothetical protein DKFZp547J097 variant, clone: CBL01641.
AB075512 - Homo sapiens neuroblastoma cDNA, clone:Nbla00487, full insert sequence.
BC047303 - Homo sapiens chromosome 6 open reading frame 134, mRNA (cDNA clone MGC:54124 IMAGE:4914615), complete cds.
AL833858 - Homo sapiens mRNA; cDNA DKFZp547J097 (from clone DKFZp547J097).
BC025755 - Homo sapiens chromosome 6 open reading frame 134, mRNA (cDNA clone IMAGE:5202281), complete cds.
AK297661 - Homo sapiens cDNA FLJ55872 complete cds.
DQ579748 - Homo sapiens piRNA piR-47860, complete sequence.
CU693052 - Synthetic construct Homo sapiens gateway clone IMAGE:100020610 5' read C6orf134 mRNA.
KJ901127 - Synthetic construct Homo sapiens clone ccsbBroadEn_10521 ATAT1 gene, encodes complete protein.
LF341334 - JP 2014500723-A/148837: Polycomb-Associated Non-Coding RNAs.
LF341333 - JP 2014500723-A/148836: Polycomb-Associated Non-Coding RNAs.
MA446388 - JP 2018138019-A/18314: Polycomb-Associated Non-Coding RNAs.
MA576911 - JP 2018138019-A/148837: Polycomb-Associated Non-Coding RNAs.
MA576910 - JP 2018138019-A/148836: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5SQI0 (Reactome details) participates in the following event(s):

R-HSA-5618328 ATAT acetylates microtubules
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf134, MEC17, Nbla00487, NM_001031722, NP_001026892, Q5SQI0-2
UCSC ID: uc003nqv.3
RefSeq Accession: NM_001031722
Protein: Q5SQI0-2, splice isoform of Q5SQI0 CCDS: CCDS54978.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001031722.2
exon count: 13CDS single in 3' UTR: no RNA size: 1740
ORF size: 1230CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2281.00frame shift in genome: no % Coverage: 99.20
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.