Human Gene TNF (uc003nuj.3)
  Description: Homo sapiens tumor necrosis factor (TNF), mRNA.
RefSeq Summary (NM_000594): This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:31,544,292-31,546,112 Size: 1,821 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr6:31,545,058-31,545,576 Size: 519 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,544,292-31,546,112)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMalacardsMGIPubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TNF
CDC HuGE Published Literature: TNF
Positive Disease Associations: acute renal allograft rejection , alcohol abuse , allergic rhinitis , allograft dysfunction, renal , allograft outcome , Alzheimer's Disease , Alzheimer's disease; dementia , ankylosing spondylitis , Arthritis, Rheumatoid| , asthma , asthma, aspirin-intolerant , Asthma. Allergy. , Asthma| , atherosclerosis, coronary , beta-Thalassemia , bone mineral density , Bone mineral mass , breast cancer , brucellosis , C-reactive protein , Carbamazepine hypersensitivity , Carcinoma, Hepatocellular|Liver Neoplasms , celiac , celiac disease , cerebral malaria , chemotherapy-induced pulmonary fibrosis , chorioamnionitis , chronic active hepatitis C infection. , chronic bronchitis , chronic GVHD , chronic obstructive pulmonary disease/COPD; bronchiectatic disease , cirrhosis , cirrhosis, alcoholic , cirrhosis, biliary primary; hepatitis, autoimmune , coal workers' pneumoconiosis (CWP) , contact hypersensitivity , COPD , Crohn's disease , Crohn's disease inflammatory bowel disease ulcerative colitis , Crohn's disease ulcerative colitis , Crohn's disease; ulcerative colitis , Delayed Graft Function|Inflammation , dermatitis herpetiformis. , Diabetes mellitus type II|Diabetes Mellitus, Type 2|Glucose Intolerance|Overweight , diabetes, type 1 , diabetes, type 2 , emphysema , endometriosis , Excessive fat accumulation , fibrosing alveolitis , graft-versus-host disease , Graves' disease , GVHD , head and neck cancer , Helicobacter pylori cagA subtype infection , hematopoietic stem cell transplantation , hepatitis B , HIV disease , human narcolepsy. , Hypertension/complications* , hypertension; cirrhosis , hypothyroidism , increased cardiopulmonary morbidity , increased development of adult T-cell leukemia/lymphoma , inflammatory bowel disease , insulin resistance in obesity , interleukin-1 beta (IL-1 beta) synthesis capacity , irritant contact dermatitis , kawasaki disease , kidney failure, chronic , kidney transplant , kidney transplant complications , Leishmania chagasi infection , lep. Leprosy , limb deficiency anomalies , lipodystrophy , Longevity , lung function , Lupus , lupus erythematosus; rheumatoid arthritis; Sjogren's syndrome; tuberculosis , malaria , malarial anemia and cerebral malaria , meliodosis , meningococcal disease. , Meningococcal Infections|Sepsis , migraine , Migraine Disorders , mucocutaneous leishmaniasis , multiple sclerosis , myasthenia gravis , myelopathy, HTLV-1 associated , Natural Menopause|Obesity|POF - Premature ovarian failure|POLYCYSTIC OVARIAN SYNDROME|Polycystic Ovary Syndrome|Primary Ovarian Insufficiency|Puberty, Delayed|Puberty, Precocious|Thrombophilia|Tobacco Use Disorder , noncardia gastric cancer , Obesity ????????? , Obesity- associated hypertension ??????? , oral cancer , pancreatitis , parvovirus B19 infection , periodontitis , Plasmodium falciparum reinfections , Polyendocrinopathies, Autoimmune , pre-term delivery infant mortality and malaria morbidity , preterm delivery , Primary Billiary Cirrosis , primary sclerosing cholangitis , psoriasis , recurrent pregnancy loss , rheumatoid arthritis , Scarring trachoma , schizophrenia , sclerosis, systemic , sepsis , sepsis; systemic inflammatory response syndrome , Silicosis , stomach cancer , stomach cancer; gastritis , stroke, hemorrhagic stroke, ischemic , subarachnoid hemorrhage , synthetic hemodialysis graft failure , testicular cancer , thyroid-associated ophthalmopathy , tuberculosis , Typhoid Fever , ulcerative colitis and Crohn's disease , Uveitis , Wounds and Injuries
Related Studies:
  1. acute renal allograft rejection
    Lee H 2004, Influence of recipient and donor IL-1alpha, IL-4, and TNFalpha genotypes on the incidence of acute renal allograft rejection., Journal of clinical pathology. 2004 Jan;57(1):101-3. [PubMed 14693849]
    This finding argues for prospective TNFA genotyping of renal donors, with avoidance of allocation of kidneys from donors positive for the TNFA-A allele to HLA-DR mismatched recipients.
  2. alcohol abuse
    Gonzalez-Quintela, A. et al. 2004, Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers., Alcohol (Fayetteville, NY). 2004 Oct-Nov;34(3-Feb):273-7. [PubMed 15902922]
    In comparison with findings for control subjects, heavy drinkers showed higher TNF-alpha production, higher IL-8 production, and higher serum IL-8 concentrations. Increased serum TNF-alpha concentrations were specifically found in heavy drinkers with the -857 (C-->T) substitution (CT heterozygotes), therefore indicating an interaction between alcohol consumption and that polymorphism on serum TNF-alpha concentrations.
  3. allergic rhinitis
    Gentile, D. A. et al. 2004, Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma., Human immunology. 2004 Apr;65(4):347-51. [PubMed 15120189]
    These results suggest a role for TNF-alpha and TGF-beta1 genotypes in the pathogenesis of allergic rhinitis and asthma, respectively. If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: TNF
Diseases sorted by gene-association score: migraine with or without aura 1* (395), asthma* (362), malaria* (273), asthma susceptibility, tnf-related* (100), arthritis (79), psoriatic arthritis (42), toxic shock syndrome (42), chorioamnionitis (36), synovitis (33), rheumatic disease (33), pulmonary sarcoidosis (31), cardiac sarcoidosis (30), colitis (28), alcoholic hepatitis (27), spondylarthropathy (25), lymphadenitis (24), listeriosis (24), chagas disease (23), mucocutaneous leishmaniasis (23), louse-borne relapsing fever (23), mycobacterium avium complex disease (23), scleritis (23), ileocolitis (22), inflammatory bowel disease (22), miller fisher syndrome (22), blau syndrome (20), spondyloarthropathy 1 (20), spondylitis (20), rheumatoid arthritis (20), trypanosomiasis (19), vasculitis (19), kashin-beck disease (19), systemic onset juvenile idiopathic arthritis (19), acute graft versus host disease (18), acute respiratory distress syndrome (18), staphylococcal toxic shock syndrome (18), new daily-persistent headache (18), actinic prurigo (18), leukomalacia (18), lymphangiosarcoma (18), spondyloarthropathy (17), pneumoconiosis (17), tonsil cancer (17), leishmaniasis (17), dengue hemorrhagic fever (17), panuveitis (17), pyoderma (17), pulmonary edema (17), hemorrhagic fever with renal syndrome (16), ileitis (16), nephropathia epidemica (16), crohn's colitis (16), sialadenitis (16), diverticulitis (16), monoclonal gammopathy of uncertain significance (16), spotted fever (15), granulomatous dermatitis (15), microscopic colitis (15), cellulitis (15), inner ear disease (15), swine influenza (15), erysipelas (15), uveitis (15), tuberculosis (15), nervous system disease (15), adult dermatomyositis (15), poliomyelitis (15), hepatitis b (15), ulcerative colitis (15), periodontal disease (15), psoriasis (15), clonorchiasis (15), pneumonia (15), adult respiratory distress syndrome (14), dry eye syndrome (14), hidradenitis suppurativa (14), aggressive periodontitis (14), pustular psoriasis (14), hidradenitis (14), rheumatic heart disease (13), plasmodium vivax malaria (13), progressive multifocal leukoencephalopathy (13), aseptic meningitis (13), punctate inner choroidopathy (13), cytomegalovirus infection (13), tuberculous meningitis (13), crimean-congo hemorrhagic fever (13), idiopathic neutropenia (13), beryllium disease (13), autoimmune inner ear disease (13), stromal keratitis (13), farmer's lung (12), fatty liver disease (12), trachoma (12), periodic fever, familial (12), hepatitis (12), sarcoidosis 1 (12), monocytic leukemia (12), paracoccidioidomycosis (12), trichuriasis (12), tympanosclerosis (12), atherosclerosis (12), brucellosis (12), peritonitis (12), pleurisy (12), primary systemic mycosis (12), aphthous stomatitis (12), complex regional pain syndrome (12), pleural tuberculosis (12), posterior uveitis (12), bone inflammation disease (11), hypersensitivity reaction type ii disease (11), retinitis pigmentosa 55 (11), endocarditis (11), retinitis pigmentosa 75 (11), connective tissue disease (11), erythema multiforme (11), dengue shock syndrome (11), myasthenia gravis (11), endometritis (11), acquired immunodeficiency syndrome (11), proctitis (11), aids dementia complex (11), pyoderma gangrenosum (11), spinal cord injury (11), multidrug-resistant tuberculosis (11), appendicitis (11), rheumatoid arthritis, systemic juvenile (11), relapsing fever (11), takayasu arteritis (11), lepromatous leprosy (11), primary bacterial infectious disease (11), subacute cutaneous lupus erythematosus (11), scorpion envenomation (11), arthropathy (11), melkersson-rosenthal syndrome (11), streptococcal toxic-shock syndrome (11), skin disease (11), choroiditis (10), microscopic polyangiitis (10), tropical endomyocardial fibrosis (10), sleep apnea (10), autoimmune myocarditis (10), periventricular leukomalacia (10), typhoid fever (10), primary progressive multiple sclerosis (10), radiation proctitis (10), q fever (10), endomyocardial fibrosis (10), granulocytopenia (10), melioidosis (10), acute gonococcal salpingitis (10), periodontitis (10), liver disease (10), arthus reaction (10), silicosis (10), avian influenza (10), skin conditions (10), joint disorders (10), pulpitis (10), viral encephalitis (10), adult-onset still's disease (10), meconium aspiration syndrome (10), guillain-barre syndrome (10), rheumatoid lung disease (10), fasciitis (10), oral tuberculosis (10), poems syndrome (10), neuritis (10), autoinflammation, lipodystrophy, and dermatosis syndrome (10), hematopoietic stem cell transplantation (9), bacterial meningitis (9), alveolar echinococcosis (9), reactive arthritis (9), hepatitis a (9), contact dermatitis (9), rheumatic fever (9), burns (9), angioimmunoblastic lymphadenopathy with dysproteinemia (9), chronic beryllium disease (9), hemorrhagic fever (9), critical limb ischemia (9), leptospirosis (9), scrub typhus (9), obstructive sleep apnea (9), cutaneous lupus erythematosus (9), lung disease (9), bronchiolitis obliterans (9), headache (9), skin sarcoidosis (9), intracranial hypertension (9), intermediate uveitis (9), sympathetic ophthalmia (9), visceral leishmaniasis (9), narcolepsy (9), cytomegalovirus retinitis (9), soft tissue sarcoma (9), allergic contact dermatitis (8), meningitis (8), compartment syndrome (8), alopecia areata (8), extrinsic cardiomyopathy (8), otitis media (8), lacrimal apparatus disease (8), demyelinating disease (8), obstructive jaundice (8), bacterial vaginosis (8), optic neuritis (8), retinal ischemia (8), autoinflammation, panniculitis, and dermatosis syndrome (8), eales disease (8), rosacea (8), fibrosarcoma (8), rheumatoid vasculitis (8), systemic lupus erythematosus (8), autoimmune pancreatitis (8), actinic cheilitis (8), mixed connective tissue disease (8), multifocal choroiditis (8), chronic pulmonary heart disease (8), localized scleroderma (8), pertussis (8), pyelonephritis (8), myelitis (8), cutaneous leishmaniasis (8), hepatopulmonary syndrome (8), pericarditis (8), burning mouth syndrome (8), tinea profunda (8), leprosy (8), anthracosis (8), haemophilus influenzae (8), prostatitis (7), commensal bacterial infectious disease (7), churg-strauss syndrome (7), chikungunya (7), parasitic protozoa infectious disease (7), keratitis (7), japanese encephalitis (7), multiple sclerosis, disease progression, modifier of (7), intestinal disease (7), hepatitis e (7), breast disease (7), transient hypogammaglobulinemia (7), idiopathic achalasia (7), viral infectious disease (7), kawasaki disease (7), laryngitis (7), respiratory system disease (7), schistosomiasis (7), lichen disease (7), infective endocarditis (7), macrophage activation syndrome (7), smallpox (7), tonsillitis (7), familial mediterranean fever, ar (7), systolic heart failure (7), osteomyelitis (7), sickle cell anemia (7), lichen planus (7), relapsing-remitting multiple sclerosis (7), gingivitis (7), pustulosis of palm and sole (7), protein-energy malnutrition (7), marburg hemorrhagic fever (7), trichosporonosis (7), scleral disease (7), tungiasis (7), post-transplant lymphoproliferative disease (7), irritable bowel syndrome (7), toxoplasmosis (7), bronchitis (7), melancholia (7), trench fever (7), chronic fatigue syndrome (7), dystrophinopathies (7), peptic ulcer disease (7), wegener granulomatosis (7), cystitis (7), ischemic heart disease (6), echinococcosis (6), chlamydia (6), weill-marchesani syndrome (6), anca-associated vasculitis (6), epstein-barr virus-associated gastric carcinoma (6), lichen sclerosus (6), lyme disease (6), vulvar vestibulitis syndrome (6), respiratory failure (6), alopecia universalis (6), legionellosis (6), filariasis (6), palindromic rheumatism (6), hypersensitivity reaction disease (6), gastroenteritis (6), congenital hydrocephalus (6), glossitis (6), interstitial lung disease (6), gastrointestinal system disease (6), irritant dermatitis (6), cholangitis (6), severe acute respiratory syndrome (6), duodenal ulcer (6), eye disease (6), limb ischemia (6), pleural disease (6), viral hepatitis (6), hepatitis c (6), end stage renal failure (6), carotid stenosis (6), anterior uveitis (6), bronchiolitis (6), sclerosing cholangitis (6), hepatic encephalopathy (6), gastric ulcer (6), mumps (6), listeria meningitis (6), hemophagocytic lymphohistiocytosis (6), cerebral palsy (6), plasmodium falciparum malaria (6), rubella (6), myocarditis (6), portal hypertension (6), cholesteatoma (6), purpura (6), pulmonary tuberculosis (6), stachybotrys chartarum (6), nontuberculous mycobacterial lung disease (6), posterior urethral valves (6), jejunoileitis (6), atrophic gastritis (6), hypersensitivity reaction type iv disease (6), immune system disease (6), chronic gonococcal salpingitis (6), human immunodeficiency virus infectious disease (6), familial tumoral calcinosis (6), rectal disease (6), behcet syndrome (6), retinitis pigmentosa 60 (6), early-onset schizophrenia (6), posterior scleritis (6), null-cell leukemia (5), keratoconjunctivitis (5), transverse myelitis (5), mycobacterium abscessus (5), osteoarthritis (5), orofacial granulomatosis (5), breast adenocarcinoma (5), oligoarticular juvenile idiopathic arthritis (5), pulmonary disease, chronic obstructive (5), penicilliosis (5), peroneal neuropathy (5), middle ear disease (5), severe hemophilia a (5), central nervous system vasculitis (5), pustulosis palmaris et plantaris (5), rasmussen encephalitis (5), coccidiosis (5), acute vascular insufficiency of intestine (5), inflammatory bowel disease 3 (5), osteosclerotic myeloma (5), keratoconjunctivitis sicca (5), dental pulp disease (5), bronchial disease (5), pneumocystosis (5), traumatic brain injury (5), sweat gland disease (5), acute proliferative glomerulonephritis (5), spinal cord disease (4), lupus erythematosus (4), acquired metabolic disease (4), critical illness polyneuropathy (4), acute salpingitis (4), heart disease (4), streptococcal meningitis (4), uterine disease (4), opportunistic mycosis (4), upper respiratory tract disease (4), spermatocele (4), lymph node disease (4), kaposi sarcoma (4), dilated cardiomyopathy (4), hypersensitivity reaction type iii disease (4), omenn syndrome (4), tuberculous peritonitis (4), exanthem (4), atopic dermatitis (4), osteoporosis (4), chronic salpingitis (4), perinatal necrotizing enterocolitis (4), crohn's disease (4), suppurative cholangitis (4), sudden infant death syndrome (4), geographic tongue (3), cogan syndrome (3), pre-eclampsia (3), kidney cancer (3), cerebrovascular disease (3), colorectal cancer (3), primary immunodeficiency disease (3), lateral sclerosis (3), obesity (3), alzheimer disease (3), artery disease (3), stomatitis (2), diarrhea (2), common variable immunodeficiency (2), celiac disease (2), aplastic anemia (2), chronic granulomatous disease (2), urinary bladder cancer (2), stomach cancer (2), multiple myeloma (2), tooth agenesis (2), cardiomyopathy (2), overnutrition (2), motor neuron disease (2), diabetes mellitus, noninsulin-dependent (2), breast cancer (2), myocardial infarction (2), leukocyte disease (2), glucose metabolism disease (1), mouth disease (1), female reproductive system disease (1), parasitic helminthiasis infectious disease (1), diabetes mellitus, insulin-dependent (1), nose disease (1), urinary system disease (1), macular degeneration, age-related, 1 (1), reproductive system disease (1), gastrointestinal system cancer (1), leigh syndrome (1), pulmonary fibrosis, idiopathic (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.12 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 74.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.26278-0.364 Picture PostScript Text
3' UTR -163.91536-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK314960 - Homo sapiens cDNA, FLJ95875, Homo sapiens tumor necrosis factor (TNF superfamily, member 2)(TNF), mRNA.
BC028148 - Homo sapiens tumor necrosis factor (TNF superfamily, member 2), mRNA (cDNA clone MGC:39905 IMAGE:5217636), complete cds.
X01394 - Human mRNA for tumor necrosis factor.
M10988 - Human tumor necrosis factor (TNF) mRNA.
E00423 - cDNA encoding human TNF gene and flanking sequence.
E00514 - cDNA coding human tumor necrosis factor.
E01053 - cDNA encoding human TNF precursor.
E01128 - DNA encoding human TNF precursor.
E01590 - cDNA encoding human tumor necrosis factor.
E02008 - cDNA encoding precursor of human tumor necrosis factor.
DQ891662 - Synthetic construct clone IMAGE:100004292; FLH179071.01X; RZPDo839C06130D tumor necrosis factor (TNF superfamily, member 2) (TNF) gene, encodes complete protein.
DQ894849 - Synthetic construct Homo sapiens clone IMAGE:100009309; FLH179067.01L; RZPDo839C06129D tumor necrosis factor (TNF superfamily, member 2) (TNF) gene, encodes complete protein.
AB464327 - Synthetic construct DNA, clone: pF1KB7595, Homo sapiens TNF gene for tumor necrosis factor, without stop codon, in Flexi system.
KJ892290 - Synthetic construct Homo sapiens clone ccsbBroadEn_01684 TNF gene, encodes complete protein.
E00884 - DNA sequence of human pro-TNF.
E08302 - cDNA encoding precursor of human tumor necrosis factor.
HQ201306 - Homo sapiens tumor necrosis factor-alpha mRNA, complete cds.
E00712 - cDNA encoding human tumor necrosis factor.
FJ795028 - Homo sapiens tumor necrosis factor alpha (TNF) mRNA, partial cds.
E00702 - cDNA encoding human tumor necrosis factor.
E01153 - cDNA encoding human TNF.
AB451492 - Homo sapiens TNF mRNA for tumor necrosis factor alpha, partial cds, clone: FLJ80001DABN.
AF043342 - Homo sapiens tumor necrosis factor alpha (TNFa) mRNA, partial cds.
AJ251878 - Homo sapiens partial mRNA for tumor necrosis factor alpha (TNF-alpha gene), isolate B10, exon 3.
AJ251879 - Homo sapiens partial mRNA for tumor necrosis factor alpha (TNF-alpha gene),isolate B19, exon 3.
E01052 - DNA encoding human mature TNF.
E01127 - DNA encoding protein which has TNF-like anti tumor activity.
E02672 - cDNA encoding human tumor necrosis factor-like poly peptide.
E01641 - cDNA encoding modified human tumor necrosis factor (hTNF).
E01642 - cDNA encoding modified human tumor necrosis factor (hTNF).
E01647 - cDNA endoding modified human tumor necrosis factor (hTNF).
E04591 - cDNA encoding human TNF.
AF098751 - Homo sapiens APC1 protein mRNA, partial cds.
E01925 - cDNA encoding new TNF polypeptide.
JD380278 - Sequence 361302 from Patent EP1572962.
JD054693 - Sequence 35717 from Patent EP1572962.
FW573317 - JP 2010529847-A/38: Oligonucleotides for modulation of target RNA activity.
JD184985 - Sequence 166009 from Patent EP1572962.
FW573321 - JP 2010529847-A/42: Oligonucleotides for modulation of target RNA activity.
JD495115 - Sequence 476139 from Patent EP1572962.
JD061975 - Sequence 42999 from Patent EP1572962.
JD086132 - Sequence 67156 from Patent EP1572962.
FW573319 - JP 2010529847-A/40: Oligonucleotides for modulation of target RNA activity.
FW573318 - JP 2010529847-A/39: Oligonucleotides for modulation of target RNA activity.
JD346852 - Sequence 327876 from Patent EP1572962.
FW573313 - JP 2010529847-A/34: Oligonucleotides for modulation of target RNA activity.
FW573315 - JP 2010529847-A/36: Oligonucleotides for modulation of target RNA activity.
AJ227911 - Homo sapiens partial mRNA; ID YG39-2, YG53, EE2-16F2.
FW573316 - JP 2010529847-A/37: Oligonucleotides for modulation of target RNA activity.
JD226145 - Sequence 207169 from Patent EP1572962.
JD351270 - Sequence 332294 from Patent EP1572962.
FW573322 - JP 2010529847-A/43: Oligonucleotides for modulation of target RNA activity.
JD391029 - Sequence 372053 from Patent EP1572962.
JD313727 - Sequence 294751 from Patent EP1572962.
FW573320 - JP 2010529847-A/41: Oligonucleotides for modulation of target RNA activity.
JD328621 - Sequence 309645 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04060 - Cytokine-cytokine receptor interaction
hsa04210 - Apoptosis
hsa04350 - TGF-beta signaling pathway
hsa04612 - Antigen processing and presentation
hsa04620 - Toll-like receptor signaling pathway
hsa04621 - NOD-like receptor signaling pathway
hsa04622 - RIG-I-like receptor signaling pathway
hsa04640 - Hematopoietic cell lineage
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa04930 - Type II diabetes mellitus
hsa04940 - Type I diabetes mellitus
hsa05010 - Alzheimer's disease
hsa05014 - Amyotrophic lateral sclerosis (ALS)
hsa05140 - Leishmaniasis
hsa05142 - Chagas disease
hsa05310 - Asthma
hsa05322 - Systemic lupus erythematosus
hsa05330 - Allograft rejection
hsa05332 - Graft-versus-host disease
hsa05410 - Hypertrophic cardiomyopathy (HCM)
hsa05414 - Dilated cardiomyopathy

BioCarta from NCI Cancer Genome Anatomy Project
h_inflamPathway - Cytokines and Inflammatory Response
h_mspPathway - Msp/Ron Receptor Signaling Pathway
h_nfkbPathway - NF-kB Signaling Pathway
h_freePathway - Free Radical Induced Apoptosis
h_tidPathway - Chaperones modulate interferon Signaling Pathway
h_tnfr1Pathway - TNFR1 Signaling Pathway
h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus
h_cytokinePathway - Cytokine Network
h_soddPathway - SODD/TNFR1 Signaling Pathway
h_stressPathway - TNF/Stress Related Signaling
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_granulocytesPathway - Adhesion and Diapedesis of Granulocytes
h_hsp27Pathway - Stress Induction of HSP Regulation
h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway
h_keratinocytePathway - Keratinocyte Differentiation
h_pmlPathway - Regulation of transcriptional activity by PML
h_vobesityPathway - Visceral Fat Deposits and the Metabolic Syndrome
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_il1rPathway - Signal transduction through IL1R
h_LairPathway - Cells and Molecules involved in local acute inflammatory response
h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

-  Other Names for This Gene
  Alternate Gene Symbols: E00702
UCSC ID: uc003nuj.3
RefSeq Accession: NM_000594

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: E00702.1
exon count: 3CDS single in 3' UTR: no RNA size: 1324
ORF size: 519CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 736.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 8
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 19# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.