Description: Homo sapiens BCL2-associated athanogene 6 (BAG6), transcript variant 4, mRNA. RefSeq Summary (NM_001098534): This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:31,606,805-31,620,170 Size: 13,366 Total Exon Count: 25 Strand: - Coding Region Position: hg19 chr6:31,606,908-31,619,540 Size: 12,633 Coding Exon Count: 24
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00240 - Ubiquitin family PF12057 - Domain of unknown function (DUF3538) PF13881 - Ubiquitin-2 like Rad60 SUMO-like
ModBase Predicted Comparative 3D Structure on P46379-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
