Description: Homo sapiens FYVE, RhoGEF and PH domain containing 2 (FGD2), mRNA. RefSeq Summary (NM_173558): The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr6:36,973,423-36,977,791 Size: 4,369 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr6:36,973,594-36,976,856 Size: 3,263 Coding Exon Count: 2
ID:F8WEZ2_HUMAN DESCRIPTION: SubName: Full=FYVE, RhoGEF and PH domain-containing protein 2; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on F8WEZ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
