Description: Homo sapiens potassium channel, subfamily K, member 16 (KCNK16), transcript variant 1, mRNA. RefSeq Summary (NM_001135105): The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]. Transcript (Including UTRs) Position: hg19 chr6:39,282,474-39,290,330 Size: 7,857 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr6:39,282,900-39,290,316 Size: 7,417 Coding Exon Count: 5
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): KCNK16 CDC HuGE Published Literature: KCNK16 Positive Disease Associations: Diabetes Mellitus, Type 2 Related Studies:
Diabetes Mellitus, Type 2 Yoon Shin Cho et al. Nature genetics 2012, Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians., Nature genetics.
[PubMed 22158537]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96T55-4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
