Description: Homo sapiens transcriptional regulating factor 1 (TRERF1), mRNA. RefSeq Summary (NM_033502): This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr6:42,192,669-42,419,783 Size: 227,115 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr6:42,196,083-42,237,328 Size: 41,246 Coding Exon Count: 14
ID:TREF1_HUMAN DESCRIPTION: RecName: Full=Transcriptional-regulating factor 1; AltName: Full=Breast cancer anti-estrogen resistance 2; AltName: Full=Transcriptional-regulating protein 132; AltName: Full=Zinc finger protein rapa; AltName: Full=Zinc finger transcription factor TReP-132; FUNCTION: Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. SUBUNIT: Interacts with CREBBP and EP300. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells. SIMILARITY: Contains 3 C2H2-type zinc fingers. SIMILARITY: Contains 1 ELM2 domain. SIMILARITY: Contains 1 SANT domain. SEQUENCE CAUTION: Sequence=BAA92082.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96PN7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0008134 transcription factor binding GO:0008301 DNA binding, bending GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006694 steroid biosynthetic process GO:0006707 cholesterol catabolic process GO:0007275 multicellular organism development GO:0042592 homeostatic process GO:0045893 positive regulation of transcription, DNA-templated GO:0046885 regulation of hormone biosynthetic process
US Server
