Description: Homo sapiens collagen, type XIX, alpha 1 (COL19A1), mRNA. RefSeq Summary (NM_001858): This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr6:70,576,448-70,922,157 Size: 345,710 Total Exon Count: 51 Strand: + Coding Region Position: hg19 chr6:70,589,460-70,916,978 Size: 327,519 Coding Exon Count: 50
ID:COJA1_HUMAN DESCRIPTION: RecName: Full=Collagen alpha-1(XIX) chain; AltName: Full=Collagen alpha-1(Y) chain; Flags: Precursor; FUNCTION: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. SUBUNIT: Oligomer; disulfide-linked. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). TISSUE SPECIFICITY: Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord. DOMAIN: The numerous interruptions in the triple helix may make this molecule either elastic or flexible. PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. SIMILARITY: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. SIMILARITY: Contains 11 collagen-like domains. SIMILARITY: Contains 1 laminin G-like domain. SEQUENCE CAUTION: Sequence=CAC12699.3; Type=Erroneous gene model prediction; Sequence=CAI42319.2; Type=Erroneous gene model prediction; Sequence=CAI42496.2; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14993
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.