Description: Homo sapiens filamin A interacting protein 1 (FILIP1), mRNA. RefSeq Summary (NM_015687): This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr6:76,017,800-76,072,719 Size: 54,920 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr6:76,018,407-76,072,612 Size: 54,206 Coding Exon Count: 4
ID:FLIP1_HUMAN DESCRIPTION: RecName: Full=Filamin-A-interacting protein 1; Short=FILIP; FUNCTION: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A (By similarity). SUBUNIT: Interacts with FLNA (By similarity). TISSUE SPECIFICITY: Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus. SIMILARITY: Belongs to the FILIP1 family. SEQUENCE CAUTION: Sequence=BAA91763.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH71818.1; Type=Erroneous gene model prediction; Sequence=CAH73614.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z7B0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL832009 - Homo sapiens mRNA; cDNA DKFZp451B134 (from clone DKFZp451B134); complete cds. AB529156 - Synthetic construct DNA, clone: pF1KA1275, Homo sapiens FILIP1 gene for filamin A interacting protein 1, without stop codon, in Flexi system. AM392955 - Synthetic construct Homo sapiens clone IMAGE:100002427 for hypothetical protein (FILIP1 gene). BX647178 - Homo sapiens mRNA; cDNA DKFZp686M12223 (from clone DKFZp686M12223). AK001570 - Homo sapiens cDNA FLJ10708 fis, clone NT2RP3000868, weakly similar to Human ovarian cancer downregulated myosin heavy chain homolog mRNA. AB033101 - Homo sapiens mRNA for KIAA1275 protein, partial cds. AB086011 - Homo sapiens mRNA for L-FILIP, complete cds. AK027705 - Homo sapiens cDNA FLJ14799 fis, clone NT2RP4001351, weakly similar to Human ovarian cancer downregulated myosin heavy chain homolog (Doc1) mRNA. BC136443 - Homo sapiens filamin A interacting protein 1, mRNA (cDNA clone MGC:168055 IMAGE:9020432), complete cds. BC136444 - Homo sapiens filamin A interacting protein 1, mRNA (cDNA clone MGC:168056 IMAGE:9020433), complete cds. AK290232 - Homo sapiens cDNA FLJ76071 complete cds, highly similar to Homo sapiens filamin A interacting protein 1 (FILIP1), mRNA. AM393398 - Synthetic construct Homo sapiens clone IMAGE:100002530 for hypothetical protein (FILIP1 gene). AK097021 - Homo sapiens cDNA FLJ39702 fis, clone SMINT2012122. JD562775 - Sequence 543799 from Patent EP1572962. JD360193 - Sequence 341217 from Patent EP1572962. JD438499 - Sequence 419523 from Patent EP1572962. JD058690 - Sequence 39714 from Patent EP1572962. JD086744 - Sequence 67768 from Patent EP1572962. JD196845 - Sequence 177869 from Patent EP1572962. BC029425 - Homo sapiens cDNA clone IMAGE:4616553, partial cds.