Human Gene FILIP1 (uc003phz.3)
  Description: Homo sapiens filamin A interacting protein 1 (FILIP1), mRNA.
RefSeq Summary (NM_015687): This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016].
Transcript (Including UTRs)
   Position: hg19 chr6:76,017,800-76,072,719 Size: 54,920 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr6:76,018,407-76,072,612 Size: 54,206 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:76,017,800-76,072,719)mRNA (may differ from genome)Protein (1114 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FLIP1_HUMAN
DESCRIPTION: RecName: Full=Filamin-A-interacting protein 1; Short=FILIP;
FUNCTION: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A (By similarity).
SUBUNIT: Interacts with FLNA (By similarity).
TISSUE SPECIFICITY: Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus.
SIMILARITY: Belongs to the FILIP1 family.
SEQUENCE CAUTION: Sequence=BAA91763.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH71818.1; Type=Erroneous gene model prediction; Sequence=CAH73614.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FILIP1
Diseases sorted by gene-association score: ureterocele (17)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.58 RPKM in Heart - Left Ventricle
Total median expression: 118.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.90107-0.167 Picture PostScript Text
3' UTR -140.93607-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019131 - Cortactin-binding_p2_N

Pfam Domains:
PF09727 - Cortactin-binding protein-2

ModBase Predicted Comparative 3D Structure on Q7Z7B0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AL832009 - Homo sapiens mRNA; cDNA DKFZp451B134 (from clone DKFZp451B134); complete cds.
AB529156 - Synthetic construct DNA, clone: pF1KA1275, Homo sapiens FILIP1 gene for filamin A interacting protein 1, without stop codon, in Flexi system.
AM392955 - Synthetic construct Homo sapiens clone IMAGE:100002427 for hypothetical protein (FILIP1 gene).
BX647178 - Homo sapiens mRNA; cDNA DKFZp686M12223 (from clone DKFZp686M12223).
AK001570 - Homo sapiens cDNA FLJ10708 fis, clone NT2RP3000868, weakly similar to Human ovarian cancer downregulated myosin heavy chain homolog mRNA.
AB033101 - Homo sapiens mRNA for KIAA1275 protein, partial cds.
AB086011 - Homo sapiens mRNA for L-FILIP, complete cds.
AK027705 - Homo sapiens cDNA FLJ14799 fis, clone NT2RP4001351, weakly similar to Human ovarian cancer downregulated myosin heavy chain homolog (Doc1) mRNA.
BC136443 - Homo sapiens filamin A interacting protein 1, mRNA (cDNA clone MGC:168055 IMAGE:9020432), complete cds.
BC136444 - Homo sapiens filamin A interacting protein 1, mRNA (cDNA clone MGC:168056 IMAGE:9020433), complete cds.
AK290232 - Homo sapiens cDNA FLJ76071 complete cds, highly similar to Homo sapiens filamin A interacting protein 1 (FILIP1), mRNA.
AM393398 - Synthetic construct Homo sapiens clone IMAGE:100002530 for hypothetical protein (FILIP1 gene).
AK097021 - Homo sapiens cDNA FLJ39702 fis, clone SMINT2012122.
JD562775 - Sequence 543799 from Patent EP1572962.
JD360193 - Sequence 341217 from Patent EP1572962.
JD438499 - Sequence 419523 from Patent EP1572962.
JD058690 - Sequence 39714 from Patent EP1572962.
JD086744 - Sequence 67768 from Patent EP1572962.
JD196845 - Sequence 177869 from Patent EP1572962.
BC029425 - Homo sapiens cDNA clone IMAGE:4616553, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AB033101, B2RMU6, FLIP1_HUMAN, KIAA1275, NM_015687, NP_056502, Q5VUL6, Q7Z7B0, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5
UCSC ID: uc003phz.3
RefSeq Accession: NM_015687
Protein: Q7Z7B0 (aka FLIP1_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AB033101.1
exon count: 4CDS single in 3' UTR: no RNA size: 4051
ORF size: 3345CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6757.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 842# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.