Description: Homo sapiens filamin A interacting protein 1 (FILIP1), mRNA. RefSeq Summary (NM_015687): This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr6:76,017,800-76,203,496 Size: 185,697 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr6:76,018,407-76,124,688 Size: 106,282 Coding Exon Count: 5
ID:FLIP1_HUMAN DESCRIPTION: RecName: Full=Filamin-A-interacting protein 1; Short=FILIP; FUNCTION: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A (By similarity). SUBUNIT: Interacts with FLNA (By similarity). TISSUE SPECIFICITY: Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus. SIMILARITY: Belongs to the FILIP1 family. SEQUENCE CAUTION: Sequence=BAA91763.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH71818.1; Type=Erroneous gene model prediction; Sequence=CAH73614.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z7B0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.