Description: Homo sapiens high mobility group nucleosomal binding domain 3 (HMGN3), transcript variant 3, mRNA. RefSeq Summary (NM_001201362): The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr6:79,910,962-79,944,455 Size: 33,494 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr6:79,911,966-79,944,277 Size: 32,312 Coding Exon Count: 5
ID:HMGN3_HUMAN DESCRIPTION: RecName: Full=High mobility group nucleosome-binding domain-containing protein 3; AltName: Full=Thyroid receptor-interacting protein 7; Short=TR-interacting protein 7; Short=TRIP-7; FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). SUBUNIT: Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes. INTERACTION: P62993:GRB2; NbExp=1; IntAct=EBI-1758705, EBI-401755; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. INDUCTION: By estrogen. SIMILARITY: Belongs to the HMGN family. SEQUENCE CAUTION: Sequence=AAA73877.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15651
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006325 chromatin organization GO:0008150 biological_process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus