Human Gene RWDD1 (uc003pxb.3)
Description: Homo sapiens RWD domain containing 1 (RWDD1), transcript variant 2, mRNA.
Transcript (Including UTRs)
Position: hg19 chr6:116,892,583-116,914,436 Size: 21,854 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr6:116,910,023-116,914,264 Size: 4,242 Coding Exon Count: 4
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RWDD1_HUMAN
DESCRIPTION: RecName: Full=RWD domain-containing protein 1; AltName: Full=DRG family-regulatory protein 2;
FUNCTION: Protects DRG2 from proteolytic degradation (By similarity).SUBUNIT: Interacts with DRG2. Interacts with androgen receptor (By similarity).INTERACTION: Q9Y295:DRG1; NbExp=2; IntAct=EBI-748952, EBI-719554;SIMILARITY: Belongs to the RWDD1/GIR2 family.SIMILARITY: Contains 1 RWD domain.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RWDD1
CDC HuGE Published Literature: RWDD1
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006575 - RWD-domain
IPR016135 - UBQ-conjugating_enzyme/RWD
Pfam Domains: PF16543 - DRG Family Regulatory Proteins, Tma46
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9H446
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF208726 - JP 2014500723-A/16229: Polycomb-Associated Non-Coding RNAs.AK290727 - Homo sapiens cDNA FLJ76612 complete cds, highly similar to Homo sapiens RWD domain containing 1 (RWDD1), transcript variant 1, mRNA.BC012534 - Homo sapiens cDNA clone IMAGE:4076280, containing frame-shift errors.AK301089 - Homo sapiens cDNA FLJ50243 complete cds, highly similar to RWD domain-containing protein 1.AF132958 - Homo sapiens CGI-24 protein mRNA, complete cds.BC015802 - Homo sapiens RWD domain containing 1, mRNA (cDNA clone MGC:9234 IMAGE:3909348), complete cds.BC008693 - Homo sapiens RWD domain containing 1, mRNA (cDNA clone IMAGE:3867815), with apparent retained intron.DQ895647 - Synthetic construct Homo sapiens clone IMAGE:100010107; FLH186303.01L; RZPDo839D0261D RWD domain containing 1 (RWDD1) gene, encodes complete protein.DQ892435 - Synthetic construct Homo sapiens clone IMAGE:100005065; FLH263491.01X; RZPDo839D0171D RWD domain containing 1 (RWDD1) gene, encodes complete protein.DQ892436 - Synthetic construct clone IMAGE:100005066; FLH186307.01X; RZPDo839D0271D RWD domain containing 1 (RWDD1) gene, encodes complete protein.DQ892437 - Synthetic construct Homo sapiens clone IMAGE:100005067; FLH263492.01X; RZPDo839D0371D RWD domain containing 1 (RWDD1) gene, encodes complete protein.AB528403 - Synthetic construct DNA, clone: pF1KB6974, Homo sapiens RWDD1 gene for RWD domain containing 1, without stop codon, in Flexi system.CU677453 - Synthetic construct Homo sapiens gateway clone IMAGE:100016870 5' read RWDD1 mRNA.KJ898891 - Synthetic construct Homo sapiens clone ccsbBroadEn_08285 RWDD1 gene, encodes complete protein.AF092134 - Homo sapiens PTD013 mRNA, complete cds.LF347782 - JP 2014500723-A/155285: Polycomb-Associated Non-Coding RNAs.MA583359 - JP 2018138019-A/155285: Polycomb-Associated Non-Coding RNAs.MA444303 - JP 2018138019-A/16229: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: A8K3W2, A8MT24, CGI-24, DFRP2, NM_016104, NP_057188, PTD013, Q9H446, Q9Y313, Q9Y6B3, RWDD1_HUMANUCSC ID: uc003pxb.3RefSeq Accession: NM_016104
Protein: Q9H446
(aka RWDD1_HUMAN or RWD1_HUMAN)
CCDS: CCDS43496.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_016104.2
exon count:
9 CDS single in 3' UTR:
no
RNA size:
1323
ORF size:
444 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
637.00 frame shift in genome:
no
% Coverage:
98.94
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.