Human Gene RWDD1 (uc003pxb.3)
  Description: Homo sapiens RWD domain containing 1 (RWDD1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:116,892,583-116,914,436 Size: 21,854 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr6:116,910,023-116,914,264 Size: 4,242 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:116,892,583-116,914,436)mRNA (may differ from genome)Protein (147 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RWDD1_HUMAN
DESCRIPTION: RecName: Full=RWD domain-containing protein 1; AltName: Full=DRG family-regulatory protein 2;
FUNCTION: Protects DRG2 from proteolytic degradation (By similarity).
SUBUNIT: Interacts with DRG2. Interacts with androgen receptor (By similarity).
INTERACTION: Q9Y295:DRG1; NbExp=2; IntAct=EBI-748952, EBI-719554;
SIMILARITY: Belongs to the RWDD1/GIR2 family.
SIMILARITY: Contains 1 RWD domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RWDD1
CDC HuGE Published Literature: RWDD1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.60 RPKM in Colon - Sigmoid
Total median expression: 434.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -242.80693-0.350 Picture PostScript Text
3' UTR -36.70172-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006575 - RWD-domain
IPR016135 - UBQ-conjugating_enzyme/RWD

Pfam Domains:
PF16543 - DRG Family Regulatory Proteins, Tma46

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2EBM - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9H446
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0002181 cytoplasmic translation
GO:0007569 cell aging
GO:0030521 androgen receptor signaling pathway
GO:0034599 cellular response to oxidative stress
GO:0071394 cellular response to testosterone stimulus
GO:2000825 positive regulation of androgen receptor activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005844 polysome


-  Descriptions from all associated GenBank mRNAs
  LF208726 - JP 2014500723-A/16229: Polycomb-Associated Non-Coding RNAs.
AK290727 - Homo sapiens cDNA FLJ76612 complete cds, highly similar to Homo sapiens RWD domain containing 1 (RWDD1), transcript variant 1, mRNA.
BC012534 - Homo sapiens cDNA clone IMAGE:4076280, containing frame-shift errors.
AK301089 - Homo sapiens cDNA FLJ50243 complete cds, highly similar to RWD domain-containing protein 1.
AF132958 - Homo sapiens CGI-24 protein mRNA, complete cds.
BC015802 - Homo sapiens RWD domain containing 1, mRNA (cDNA clone MGC:9234 IMAGE:3909348), complete cds.
BC008693 - Homo sapiens RWD domain containing 1, mRNA (cDNA clone IMAGE:3867815), with apparent retained intron.
DQ895647 - Synthetic construct Homo sapiens clone IMAGE:100010107; FLH186303.01L; RZPDo839D0261D RWD domain containing 1 (RWDD1) gene, encodes complete protein.
DQ892435 - Synthetic construct Homo sapiens clone IMAGE:100005065; FLH263491.01X; RZPDo839D0171D RWD domain containing 1 (RWDD1) gene, encodes complete protein.
DQ892436 - Synthetic construct clone IMAGE:100005066; FLH186307.01X; RZPDo839D0271D RWD domain containing 1 (RWDD1) gene, encodes complete protein.
DQ892437 - Synthetic construct Homo sapiens clone IMAGE:100005067; FLH263492.01X; RZPDo839D0371D RWD domain containing 1 (RWDD1) gene, encodes complete protein.
AB528403 - Synthetic construct DNA, clone: pF1KB6974, Homo sapiens RWDD1 gene for RWD domain containing 1, without stop codon, in Flexi system.
CU677453 - Synthetic construct Homo sapiens gateway clone IMAGE:100016870 5' read RWDD1 mRNA.
KJ898891 - Synthetic construct Homo sapiens clone ccsbBroadEn_08285 RWDD1 gene, encodes complete protein.
AF092134 - Homo sapiens PTD013 mRNA, complete cds.
LF347782 - JP 2014500723-A/155285: Polycomb-Associated Non-Coding RNAs.
MA583359 - JP 2018138019-A/155285: Polycomb-Associated Non-Coding RNAs.
MA444303 - JP 2018138019-A/16229: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3W2, A8MT24, CGI-24, DFRP2, NM_016104, NP_057188, PTD013, Q9H446, Q9Y313, Q9Y6B3, RWDD1_HUMAN
UCSC ID: uc003pxb.3
RefSeq Accession: NM_016104
Protein: Q9H446 (aka RWDD1_HUMAN or RWD1_HUMAN)
CCDS: CCDS43496.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_016104.2
exon count: 9CDS single in 3' UTR: no RNA size: 1323
ORF size: 444CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 637.00frame shift in genome: no % Coverage: 98.94
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.