ID:PKHG1_HUMAN DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family G member 1; PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain.
Alcoholism Lingjun Zuo et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2012, Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic.
[PubMed 22488850]
Cholesterol, HDL Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULL1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK293288 - Homo sapiens cDNA FLJ61588 partial cds, highly similar to Pleckstrin homology domain-containing family G member 1. AK307631 - Homo sapiens cDNA, FLJ97579. AB384583 - Synthetic construct DNA, clone: pF1KA1209, Homo sapiens PLEKHG1 gene for pleckstrin homology domain-containing protein, family G member 1, complete cds, without stop codon, in Flexi system. AK294798 - Homo sapiens cDNA FLJ52092 complete cds, highly similar to Pleckstrin homology domain-containing family G member 1. AK056300 - Homo sapiens cDNA FLJ31738 fis, clone NT2RI2007096, highly similar to Pleckstrin homology domain-containing family G member 1. BC140864 - Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1, mRNA (cDNA clone MGC:176541 IMAGE:9021732), complete cds. BC151134 - Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1, mRNA (cDNA clone MGC:184046 IMAGE:9057034), complete cds. AJ420468 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2072853. BC089428 - Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1, mRNA (cDNA clone IMAGE:3066302), partial cds. AB033035 - Homo sapiens mRNA for KIAA1209 protein, partial cds. JD192254 - Sequence 173278 from Patent EP1572962.