Description: Homo sapiens T-cell activation RhoGTPase activating protein (TAGAP), transcript variant 3, mRNA. RefSeq Summary (NM_138810): This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr6:159,459,944-159,466,184 Size: 6,241 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr6:159,460,128-159,465,178 Size: 5,051 Coding Exon Count: 7
Celiac Disease Karen A Hunt et al. Nature genetics 2008, Newly identified genetic risk variants for celiac disease related to the immune response., Nature genetics.
[PubMed 18311140]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48350 - GTPase activation domain, GAP
ModBase Predicted Comparative 3D Structure on Q8N103-4
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
