Description: Homo sapiens BRCA1-associated ATM activator 1 (BRAT1), mRNA. RefSeq Summary (NM_152743): The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]. Transcript (Including UTRs) Position: hg19 chr7:2,582,148-2,595,392 Size: 13,245 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr7:2,583,166-2,594,065 Size: 10,900 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q6PJG6-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
LF384065 - JP 2014500723-A/191568: Polycomb-Associated Non-Coding RNAs. BC023561 - Homo sapiens chromosome 7 open reading frame 27, mRNA (cDNA clone IMAGE:4025532), partial cds. BC007209 - Homo sapiens chromosome 7 open reading frame 27, mRNA (cDNA clone IMAGE:2905978), partial cds. BC015632 - Homo sapiens chromosome 7 open reading frame 27, mRNA (cDNA clone MGC:22916 IMAGE:3839985), complete cds. AK024461 - Homo sapiens mRNA for FLJ00053 protein, partial cds. AK131097 - Homo sapiens mRNA for FLJ00321 protein. AK024482 - Homo sapiens mRNA for FLJ00076 protein, partial cds. AK131083 - Homo sapiens mRNA for FLJ00283 protein. JD026714 - Sequence 7738 from Patent EP1572962. JD033664 - Sequence 14688 from Patent EP1572962. DQ587276 - Homo sapiens piRNA piR-54388, complete sequence. JD372461 - Sequence 353485 from Patent EP1572962. JD400848 - Sequence 381872 from Patent EP1572962. MA619642 - JP 2018138019-A/191568: Polycomb-Associated Non-Coding RNAs.