Description: Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA. RefSeq Summary (NM_005924): This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:15,650,837-15,726,308 Size: 75,472 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr7:15,652,012-15,726,027 Size: 74,016 Coding Exon Count: 3
ID:MEOX2_HUMAN DESCRIPTION: RecName: Full=Homeobox protein MOX-2; AltName: Full=Growth arrest-specific homeobox; AltName: Full=Mesenchyme homeobox 2; FUNCTION: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). SUBUNIT: Interacts with RNF10. SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. TISSUE SPECIFICITY: Embryo and placenta. DOMAIN: The polyhistidine repeat may act as a targeting signal to nuclear speckles (PubMed:19266028). POLYMORPHISM: The poly-His region of MEOX2 is polymorphic and the number of His varies in the population. SIMILARITY: Contains 1 homeobox DNA-binding domain.
Echocardiography Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903301]
In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50222
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001525 angiogenesis GO:0001757 somite specification GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007519 skeletal muscle tissue development GO:0008015 blood circulation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060021 palate development GO:0060173 limb development GO:0061053 somite development GO:0070997 neuron death GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
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