Human Gene CLK2P (uc003swk.2)
  Description: Homo sapiens CDC-like kinase 2, pseudogene (CLK2P), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr7:23,624,335-23,626,146 Size: 1,812 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr7:23,624,681-23,625,496 Size: 816 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:23,624,335-23,626,146)mRNA (may differ from genome)Protein (271 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkHGNCLynx
MGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.56 RPKM in Testis
Total median expression: 42.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -254.00650-0.391 Picture PostScript Text
3' UTR -93.30346-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on A4D151
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation


-  Descriptions from all associated GenBank mRNAs
  JD494740 - Sequence 475764 from Patent EP1572962.
JD375529 - Sequence 356553 from Patent EP1572962.
JD297398 - Sequence 278422 from Patent EP1572962.
JD097941 - Sequence 78965 from Patent EP1572962.
BC022025 - Homo sapiens CDC-like kinase 2, pseudogene, mRNA (cDNA clone IMAGE:4824890).
JD548829 - Sequence 529853 from Patent EP1572962.
JD272693 - Sequence 253717 from Patent EP1572962.
JD375096 - Sequence 356120 from Patent EP1572962.
JD539051 - Sequence 520075 from Patent EP1572962.
JD314844 - Sequence 295868 from Patent EP1572962.
JD377606 - Sequence 358630 from Patent EP1572962.
JD055831 - Sequence 36855 from Patent EP1572962.
JD328158 - Sequence 309182 from Patent EP1572962.
JD042912 - Sequence 23936 from Patent EP1572962.
JD138799 - Sequence 119823 from Patent EP1572962.
JD476088 - Sequence 457112 from Patent EP1572962.
JD409353 - Sequence 390377 from Patent EP1572962.
JD226631 - Sequence 207655 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D151, A4D151_HUMAN, LOC402468, NR_002711, tcag7.1259
UCSC ID: uc003swk.2
RefSeq Accession: NR_002711
Protein: A4D151

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_002711.3
exon count: 1CDS single in 3' UTR: no RNA size: 1812
ORF size: 816CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 851.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.