Description: Homo sapiens corticotropin releasing hormone receptor 2 (CRHR2), transcript variant 3, mRNA. RefSeq Summary (NM_001202481): The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr7:30,721,836-30,739,719 Size: 17,884 Total Exon Count: 4 Strand: -
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
U34587 - Human corticotropin-releasing factor receptor 2 mRNA, complete cds. AF019381 - Homo sapiens corticotropin releasing hormone receptor type 2 gamma isoform (CRH2R) mRNA, complete cds. AF011406 - Homo sapiens corticotropin releasing hormone receptor type 2 beta isoform (CRH2R) mRNA, complete cds. BC096830 - Homo sapiens corticotropin releasing hormone receptor 2, mRNA (cDNA clone MGC:111704 IMAGE:6971903), complete cds. AY449734 - Homo sapiens corticotropin-releasing hormone receptor 2 (CRHR2) mRNA, complete cds. EU012439 - Homo sapiens CRF2 receptor isoform D (CRHR2) mRNA, complete cds. EU012440 - Homo sapiens CRF2 receptor isoform E (CRHR2) mRNA, complete cds. EU012442 - Homo sapiens CRF2 receptor isoform G (CRHR2) mRNA, complete cds. EU012443 - Homo sapiens CRF2a receptor isoform desQ (CRHR2) mRNA, complete cds. FJ200484 - Homo sapiens CRH receptor 2 variant B mRNA, complete cds. AK313661 - Homo sapiens cDNA, FLJ94241, highly similar to Homo sapiens corticotropin releasing hormone receptor 2 (CRHR2), mRNA. EU012441 - Homo sapiens CRF2 recepter isoform F (CRHR2) mRNA, complete cds. Y10151 - H.sapiens mRNA for CRF2 receptor, beta isoform, partial. Y10152 - H.sapiens mRNA for CRF2 receptor, beta isoform, aberrantly spliced, (94bp deletion). Y10153 - H.sapiens mRNA for CRF2 receptor, beta isoform, aberrantly spliced, (227bp insertion). AF361106 - Homo sapiens CRHF2 receptor beta-isoform mRNA, partial sequence, aberrantly spliced. AF361107 - Homo sapiens CRHF2 receptor beta-isoform mRNA, partial sequence, aberrantly spliced. AF361108 - Homo sapiens CRHF2 receptor beta-isoform mRNA, partial sequence, aberrantly spliced.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction