Human Gene ADCYAP1R1 (uc003tcc.2)
  Description: Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), transcript variant 3, mRNA.
RefSeq Summary (NM_001199637): This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr7:31,102,810-31,151,093 Size: 48,284 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr7:31,102,881-31,146,298 Size: 43,418 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:31,102,810-31,151,093)mRNA (may differ from genome)Protein (496 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMalacardsMGIOMIMPubMed
TreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E9PFU5_HUMAN
DESCRIPTION: SubName: Full=Pituitary adenylate cyclase-activating polypeptide type I receptor;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ADCYAP1R1
CDC HuGE Published Literature: ADCYAP1R1
Positive Disease Associations: Attention Deficit Disorder with Hyperactivity , Depressive Disorder, Major , Electrocardiography , Exercise Test , Macular Degeneration , Triglycerides
Related Studies:
  1. Attention Deficit Disorder with Hyperactivity
    , , . [PubMed 0]
  2. Depressive Disorder, Major
    , , . [PubMed 0]
  3. Depressive Disorder, Major
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: ADCYAP1R1
Diseases sorted by gene-association score: post-traumatic stress disorder (10), anxiety disorder (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.03 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 386.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.0071-0.423 Picture PostScript Text
3' UTR -1839.404795-0.384 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR002285 - GPCR_2_PACAP_1_rcpt
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF02793 - Hormone receptor domain

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain (HRM, Pfam 02793)

ModBase Predicted Comparative 3D Structure on E9PFU5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK290046 - Homo sapiens cDNA FLJ76767 complete cds, highly similar to Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), mRNA.
AK226138 - Homo sapiens mRNA for type I adenylate cyclase activating polypeptide receptor precursor variant, clone: pf00023.
BC136267 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:167877 IMAGE:9020254), complete cds.
BC117116 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:150725 IMAGE:40125667), complete cds.
BC143679 - Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, mRNA (cDNA clone MGC:177210 IMAGE:9052193), complete cds.
D17516 - Homo sapiens mRNA for PACAP receptor, complete cds.
E10374 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-A.
E10375 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-B.
E10376 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-B2.
E10377 - cDNA encoding Pituitary Adenylate Cyclase Activating Polypeptide receptor I-C.
HQ258442 - Synthetic construct Homo sapiens clone IMAGE:100072871 Unknown protein gene, encodes complete protein.
AY366498 - Homo sapiens pituitary adenyl cyclase activating polypeptide 1 receptor type 1 (ADCYAP1R1) mRNA, complete cds.
AY462278 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop splice variant (ADCYAP1R1) mRNA, partial cds; alternatively spliced.
AY462279 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hop splice variant (ADCYAP1R1) mRNA, partial cds; alternatively spliced.
AY495951 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I Hip variant (ADCYAP1R1) mRNA, partial cds, alternatively spliced.
AY495952 - Homo sapiens pituitary adenylate cyclase activating polypeptide 1 receptor type I HopII variant (ADCYAP1R1) mRNA, partial cds, alternatively spliced.
BX538156 - Homo sapiens mRNA; cDNA DKFZp686A0650 (from clone DKFZp686A0650).
AK096545 - Homo sapiens cDNA FLJ39226 fis, clone OCBBF2007232.
JD356047 - Sequence 337071 from Patent EP1572962.
JD378114 - Sequence 359138 from Patent EP1572962.
JD200042 - Sequence 181066 from Patent EP1572962.
JD490579 - Sequence 471603 from Patent EP1572962.
JD466532 - Sequence 447556 from Patent EP1572962.
JD545893 - Sequence 526917 from Patent EP1572962.
JD088716 - Sequence 69740 from Patent EP1572962.
JD330436 - Sequence 311460 from Patent EP1572962.
JD175240 - Sequence 156264 from Patent EP1572962.
JD424643 - Sequence 405667 from Patent EP1572962.
JD448905 - Sequence 429929 from Patent EP1572962.
JD190098 - Sequence 171122 from Patent EP1572962.
JD271204 - Sequence 252228 from Patent EP1572962.
JD536141 - Sequence 517165 from Patent EP1572962.
JD402628 - Sequence 383652 from Patent EP1572962.
JD411584 - Sequence 392608 from Patent EP1572962.
JD264643 - Sequence 245667 from Patent EP1572962.
JD208335 - Sequence 189359 from Patent EP1572962.
JD491112 - Sequence 472136 from Patent EP1572962.
JD490567 - Sequence 471591 from Patent EP1572962.
JD200954 - Sequence 181978 from Patent EP1572962.
AK124304 - Homo sapiens cDNA FLJ42311 fis, clone TRACH2008300.
JD290960 - Sequence 271984 from Patent EP1572962.
JD237444 - Sequence 218468 from Patent EP1572962.
JD545637 - Sequence 526661 from Patent EP1572962.
JD566290 - Sequence 547314 from Patent EP1572962.
JD444097 - Sequence 425121 from Patent EP1572962.
JD213804 - Sequence 194828 from Patent EP1572962.
JD430846 - Sequence 411870 from Patent EP1572962.
JD326333 - Sequence 307357 from Patent EP1572962.
JD492850 - Sequence 473874 from Patent EP1572962.
JD218656 - Sequence 199680 from Patent EP1572962.
JD494711 - Sequence 475735 from Patent EP1572962.
JD453035 - Sequence 434059 from Patent EP1572962.
JD135074 - Sequence 116098 from Patent EP1572962.
JD092677 - Sequence 73701 from Patent EP1572962.
JD243125 - Sequence 224149 from Patent EP1572962.
JD344612 - Sequence 325636 from Patent EP1572962.
JD048611 - Sequence 29635 from Patent EP1572962.
JD369620 - Sequence 350644 from Patent EP1572962.
JD340497 - Sequence 321521 from Patent EP1572962.
JD368967 - Sequence 349991 from Patent EP1572962.
JD263090 - Sequence 244114 from Patent EP1572962.
JD293792 - Sequence 274816 from Patent EP1572962.
JD536838 - Sequence 517862 from Patent EP1572962.
JD524118 - Sequence 505142 from Patent EP1572962.
JD206361 - Sequence 187385 from Patent EP1572962.
JD231824 - Sequence 212848 from Patent EP1572962.
JD247863 - Sequence 228887 from Patent EP1572962.
JD444530 - Sequence 425554 from Patent EP1572962.
JD137293 - Sequence 118317 from Patent EP1572962.
JD162502 - Sequence 143526 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

-  Other Names for This Gene
  Alternate Gene Symbols: E10377, E9PFU5, E9PFU5_HUMAN, NM_001199637, NP_001186564
UCSC ID: uc003tcc.2
RefSeq Accession: NM_001199637
Protein: E9PFU5

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: E10377.1
exon count: 16CDS single in 3' UTR: no RNA size: 1748
ORF size: 1491CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3074.00frame shift in genome: no % Coverage: 90.10
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.