Description: Homo sapiens biliverdin reductase A (BLVRA), transcript variant 1, mRNA. RefSeq Summary (NM_000712): The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]. Transcript (Including UTRs) Position: hg19 chr7:43,798,272-43,846,941 Size: 48,670 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr7:43,810,758-43,846,834 Size: 36,077 Coding Exon Count: 7
ID:BIEA_HUMAN DESCRIPTION: RecName: Full=Biliverdin reductase A; Short=BVR A; EC=1.3.1.24; AltName: Full=Biliverdin-IX alpha-reductase; Flags: Precursor; FUNCTION: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. CATALYTIC ACTIVITY: Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H. COFACTOR: Binds 1 zinc ion per subunit. PATHWAY: Porphyrin metabolism; protoheme degradation. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Liver. DISEASE: Defects in BLVRA are the cause of hyperbiliverdinemia (HBLVD) [MIM:614156]. HBLVD is a condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. MISCELLANEOUS: Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems. SIMILARITY: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/blvra/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53004
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.