Description: Homo sapiens actin related protein 2/3 complex, subunit 1A, 41kDa (ARPC1A), transcript variant 1, mRNA. RefSeq Summary (NM_006409): This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr7:98,923,496-98,963,885 Size: 40,390 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr7:98,930,977-98,963,552 Size: 32,576 Coding Exon Count: 9
ID:ARC1A_HUMAN DESCRIPTION: RecName: Full=Actin-related protein 2/3 complex subunit 1A; AltName: Full=SOP2-like protein; FUNCTION: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. SUBUNIT: Probable component of the Arp2/3 complex in which it may replace ARPC1B. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). SIMILARITY: Belongs to the WD repeat ARPC1 family. SIMILARITY: Contains 6 WD repeats.
Dehydroepiandrosterone Sulfate Guangju Zhai et al. PLoS genetics 2011, Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms., PLoS genetics.
[PubMed 21533175]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92747
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
