Description: Homo sapiens ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (ATP5MF), nuclear gene encoding mitochondrial protein, transcript variant 4, mRNA. RefSeq Summary (NM_001039178): Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr7:99,055,784-99,063,824 Size: 8,041 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr7:99,055,950-99,063,764 Size: 7,815 Coding Exon Count: 3
ID:C9J8H9_HUMAN DESCRIPTION: SubName: Full=ATP synthase subunit f, mitochondrial; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10206 - Mitochondrial F1F0-ATP synthase, subunit f
ModBase Predicted Comparative 3D Structure on C9J8H9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
