Description: Homo sapiens armadillo repeat containing 10 (ARMC10), transcript variant A, mRNA. RefSeq Summary (NM_031905): This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr7:102,715,328-102,740,210 Size: 24,883 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr7:102,715,720-102,739,000 Size: 23,281 Coding Exon Count: 7
ID:ARM10_HUMAN DESCRIPTION: RecName: Full=Armadillo repeat-containing protein 10; AltName: Full=Splicing variant involved in hepatocarcinogenesis protein; FUNCTION: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. SUBUNIT: Interacts with the DNA-binding domain of p53/TP53. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain. MISCELLANEOUS: Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity. SIMILARITY: Contains 1 ARM repeat. SEQUENCE CAUTION: Sequence=AAS07482.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N2F6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0040008 regulation of growth GO:0040010 positive regulation of growth rate GO:0043066 negative regulation of apoptotic process GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
US Server
