Human Gene DPY19L2P2 (uc003vbh.4)
  Description: Homo sapiens dpy-19-like 2 pseudogene 2 (C. elegans) (DPY19L2P2), transcript variant 2, non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr7:102,815,462-102,920,759 Size: 105,298 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr7:102,815,838-102,898,908 Size: 83,071 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:102,815,462-102,920,759)mRNA (may differ from genome)Protein (376 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkH-INVHGNC
LynxMGIneXtProtPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: D19P2_HUMAN
DESCRIPTION: RecName: Full=Putative protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Fibroblast, lung, lymphoblast, spleen and testis.
SIMILARITY: Belongs to the dpy-19 family.
CAUTION: Could be the product of a pseudogene.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.65 RPKM in Testis
Total median expression: 67.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -878.572191-0.401 Picture PostScript Text
3' UTR -77.06376-0.205 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018732 - Dpy-19

Pfam Domains:
PF10034 - Q-cell neuroblast polarisation

ModBase Predicted Comparative 3D Structure on Q6ZN68
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000030 mannosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups

Biological Process:
GO:0007286 spermatid development
GO:0018406 protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan

Cellular Component:
GO:0005637 nuclear inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AL834175 - Homo sapiens mRNA; cDNA DKFZp434E092 (from clone DKFZp434E092).
BC033022 - Homo sapiens hypothetical protein FLJ36166, mRNA (cDNA clone IMAGE:4828044), **** WARNING: chimeric clone ****.
AK093485 - Homo sapiens cDNA FLJ36166 fis, clone TESTI2026104, weakly similar to DPY-19 PROTEIN.
AX748159 - Sequence 1684 from Patent EP1308459.
BC150309 - Homo sapiens cDNA clone IMAGE:8860440.
BC094802 - Homo sapiens cDNA clone IMAGE:5271477, containing frame-shift errors.
AK131353 - Homo sapiens cDNA FLJ16377 fis, clone TKIDN2012771, weakly similar to DPY-19 PROTEIN.
AK097711 - Homo sapiens cDNA FLJ40392 fis, clone TESTI2036913.
BC045595 - Homo sapiens hypothetical protein FLJ36166, mRNA (cDNA clone IMAGE:5297461).
JD410628 - Sequence 391652 from Patent EP1572962.
AL049437 - Homo sapiens mRNA; cDNA DKFZp586E1120 (from clone DKFZp586E1120).
BX648212 - Homo sapiens mRNA; cDNA DKFZp779M0267 (from clone DKFZp779M0267).
BC068601 - Homo sapiens dpy-19-like 2 pseudogene 2 (C. elegans), mRNA (cDNA clone IMAGE:5270486).
BC023575 - Homo sapiens hypothetical protein FLJ36166, mRNA (cDNA clone IMAGE:4590889).
JD318750 - Sequence 299774 from Patent EP1572962.
JD325827 - Sequence 306851 from Patent EP1572962.
JD483838 - Sequence 464862 from Patent EP1572962.
JD408060 - Sequence 389084 from Patent EP1572962.
AK302046 - Homo sapiens cDNA FLJ57226 complete cds.
JD464447 - Sequence 445471 from Patent EP1572962.
JD378763 - Sequence 359787 from Patent EP1572962.
JD267379 - Sequence 248403 from Patent EP1572962.
KJ900966 - Synthetic construct Homo sapiens clone ccsbBroadEn_10360 DPY19L2P2 gene, encodes complete protein.
JD195781 - Sequence 176805 from Patent EP1572962.
JD437457 - Sequence 418481 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D19P2_HUMAN, NR_003561, Q6ZN68, Q8N9V4, Q8ND62
UCSC ID: uc003vbh.4
RefSeq Accession: NR_003561
Protein: Q6ZN68 (aka D19P2_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_003561.2
exon count: 21CDS single in 3' UTR: no RNA size: 3700
ORF size: 1131CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 734.50frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.