Human Gene SMO (uc003vos.3)
Description: Homo sapiens smoothened, frizzled family receptor (SMO), mRNA.
RefSeq Summary (NM_005631): The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010].
Transcript (Including UTRs)
Position: hg19 chr7:128,845,991-128,853,385 Size: 7,395 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr7:128,846,046-128,851,733 Size: 5,688 Coding Exon Count: 7
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SMO
CDC HuGE Published Literature: SMO
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF213729 - JP 2014500723-A/21232: Polycomb-Associated Non-Coding RNAs.LF207062 - JP 2014500723-A/14565: Polycomb-Associated Non-Coding RNAs.BC009989 - Homo sapiens smoothened homolog (Drosophila), mRNA (cDNA clone MGC:15193 IMAGE:4127774), complete cds.AF120103 - Homo sapiens Gx protein mRNA, complete cds.AB587396 - Synthetic construct DNA, clone: pF1KB5715, Homo sapiens SMO gene for smoothened homolog, without stop codon, in Flexi system.DQ896647 - Synthetic construct Homo sapiens clone IMAGE:100011107; FLH196247.01L; RZPDo839G05153D smoothened homolog (Drosophila) (SMO) gene, encodes complete protein.U84401 - Human smoothened mRNA, complete cds.AF071494 - Homo sapiens Gx protein (GX) mRNA, complete cds.MA449306 - JP 2018138019-A/21232: Polycomb-Associated Non-Coding RNAs.MA442639 - JP 2018138019-A/14565: Polycomb-Associated Non-Coding RNAs.BC004332 - Homo sapiens smoothened homolog (Drosophila), mRNA (cDNA clone IMAGE:3630958), with apparent retained intron.LF360949 - JP 2014500723-A/168452: Polycomb-Associated Non-Coding RNAs.LF360951 - JP 2014500723-A/168454: Polycomb-Associated Non-Coding RNAs.AF130867 - Homo sapiens smoothened mRNA, partial cds.JD240231 - Sequence 221255 from Patent EP1572962.JD045119 - Sequence 26143 from Patent EP1572962.JD283044 - Sequence 264068 from Patent EP1572962.LF360952 - JP 2014500723-A/168455: Polycomb-Associated Non-Coding RNAs.JD212159 - Sequence 193183 from Patent EP1572962.JD487799 - Sequence 468823 from Patent EP1572962.JD562359 - Sequence 543383 from Patent EP1572962.JD157543 - Sequence 138567 from Patent EP1572962.JD192649 - Sequence 173673 from Patent EP1572962.JD535526 - Sequence 516550 from Patent EP1572962.JD279166 - Sequence 260190 from Patent EP1572962.JD073611 - Sequence 54635 from Patent EP1572962.JD307569 - Sequence 288593 from Patent EP1572962.JD058029 - Sequence 39053 from Patent EP1572962.JD051879 - Sequence 32903 from Patent EP1572962.AF089720 - Homo sapiens smoothened mRNA, 3' UTR.JD552424 - Sequence 533448 from Patent EP1572962.JD203418 - Sequence 184442 from Patent EP1572962.JD516033 - Sequence 497057 from Patent EP1572962.JD503647 - Sequence 484671 from Patent EP1572962.JD041581 - Sequence 22605 from Patent EP1572962.JD427374 - Sequence 408398 from Patent EP1572962.JD523960 - Sequence 504984 from Patent EP1572962.JD476593 - Sequence 457617 from Patent EP1572962.JD147845 - Sequence 128869 from Patent EP1572962.JD494029 - Sequence 475053 from Patent EP1572962.JD074388 - Sequence 55412 from Patent EP1572962.JD554542 - Sequence 535566 from Patent EP1572962.JD250780 - Sequence 231804 from Patent EP1572962.JD187816 - Sequence 168840 from Patent EP1572962.MA596526 - JP 2018138019-A/168452: Polycomb-Associated Non-Coding RNAs.MA596528 - JP 2018138019-A/168454: Polycomb-Associated Non-Coding RNAs.MA596529 - JP 2018138019-A/168455: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04340 - Hedgehog signaling pathwayhsa05200 - Pathways in cancerhsa05217 - Basal cell carcinoma
Other Names for This Gene
Alternate Gene Symbols: BC004332UCSC ID: uc003vos.3RefSeq Accession: NM_005631
GeneReviews for This Gene
GeneReviews article(s) related to gene SMO:evc (Ellis-van Creveld Syndrome)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
BC004332.1
exon count:
7 CDS single in 3' UTR:
no
RNA size:
2646
ORF size:
1083 CDS single in intron:
no
Alignment % ID:
99.88
txCdsPredict score:
2340.00 frame shift in genome:
no
% Coverage:
97.69
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
yes
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
1774 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.