ID:COPG2_HUMAN DESCRIPTION: RecName: Full=Coatomer subunit gamma-2; AltName: Full=Gamma-2-coat protein; Short=Gamma-2-COP; FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). SUBUNIT: Oligomeric complex. Binds to CDC42. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). SIMILARITY: Belongs to the COPG family. SIMILARITY: Contains 6 HEAT repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48371 - ARM repeat 48431 - Lipovitellin-phosvitin complex, superhelical domain 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain
ModBase Predicted Comparative 3D Structure on Q9UBF2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006891 intra-Golgi vesicle-mediated transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport
HM005552 - Homo sapiens clone HTL-S-12 testicular secretory protein Li 12 mRNA, complete cds. LF384090 - JP 2014500723-A/191593: Polycomb-Associated Non-Coding RNAs. AK002086 - Homo sapiens cDNA FLJ11224 fis, clone PLACE1008273, moderately similar to COATOMER GAMMA SUBUNIT. AK024414 - Homo sapiens cDNA FLJ14352 fis, clone Y79AA1000346, highly similar to Coatomer subunit gamma-2. AF157833 - Homo sapiens nonclathrin coat protein gamma2-COP mRNA, complete cds. AF207598 - Homo sapiens coat protein gamma2-COP (COPG2) mRNA, complete cds. BC017443 - Homo sapiens coatomer protein complex, subunit gamma 2, mRNA (cDNA clone IMAGE:3353446), partial cds. AB047847 - Homo sapiens mRNA for gamma2-COP, complete cds. AK022934 - Homo sapiens cDNA FLJ12872 fis, clone NT2RP2003760, highly similar to COATOMER GAMMA SUBUNIT. AK291409 - Homo sapiens cDNA FLJ77552 complete cds, highly similar to Homo sapiens nonclathrin coat protein gamma2-COP mRNA. MA619667 - JP 2018138019-A/191593: Polycomb-Associated Non-Coding RNAs. LF361144 - JP 2014500723-A/168647: Polycomb-Associated Non-Coding RNAs. JD240116 - Sequence 221140 from Patent EP1572962. JD040653 - Sequence 21677 from Patent EP1572962. AF308295 - Homo sapiens serologically defined breast cancer antigen NY-BR-73 mRNA, partial cds. LF361145 - JP 2014500723-A/168648: Polycomb-Associated Non-Coding RNAs. JD453133 - Sequence 434157 from Patent EP1572962. MA596721 - JP 2018138019-A/168647: Polycomb-Associated Non-Coding RNAs. MA596722 - JP 2018138019-A/168648: Polycomb-Associated Non-Coding RNAs. BC110796 - Homo sapiens coatomer protein complex, subunit gamma 2, mRNA (cDNA clone MGC:131645 IMAGE:5197024), complete cds. BC038415 - Homo sapiens testis specific, 13, mRNA (cDNA clone MGC:35224 IMAGE:5172129), complete cds. AK093329 - Homo sapiens cDNA FLJ36010 fis, clone TESTI2015938, highly similar to Homo sapiens testis specific, 13 (TSGA13), mRNA. AX748057 - Sequence 1582 from Patent EP1308459. JD195378 - Sequence 176402 from Patent EP1572962. JD140031 - Sequence 121055 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UBF2 (Reactome details) participates in the following event(s):
R-HSA-6807872 Active ARF recruits coatomer R-HSA-6811412 Active ARF recruits coatomer to the Golgi R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
