Description: Homo sapiens ATPase, H+ transporting V0 subunit e2 (ATP6V0E2), transcript variant 2, mRNA. RefSeq Summary (NM_001100592): Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr7:149,570,057-149,575,686 Size: 5,630 Total Exon Count: 3 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK057700 - Homo sapiens cDNA FLJ33138 fis, clone UTERU1000096, weakly similar to VACUOLAR ATP SYNTHASE SUBUNIT H (EC 3.6.1.34). AF452639 - Homo sapiens tissue-type placenta hypothetical protein mRNA, complete cds. JD200517 - Sequence 181541 from Patent EP1572962. JD210408 - Sequence 191432 from Patent EP1572962. JD128868 - Sequence 109892 from Patent EP1572962. DQ989009 - Homo sapiens H+-ATPase e2 subunit (ATP6V0E2) mRNA, complete cds. JD462703 - Sequence 443727 from Patent EP1572962. JD478377 - Sequence 459401 from Patent EP1572962. LF207125 - JP 2014500723-A/14628: Polycomb-Associated Non-Coding RNAs. BX640846 - Homo sapiens mRNA; cDNA DKFZp686N23273 (from clone DKFZp686N23273); complete cds. AK290086 - Homo sapiens cDNA FLJ77720 complete cds. AK094602 - Homo sapiens cDNA FLJ37283 fis, clone BRAMY2013414, moderately similar to ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9kD. AK098362 - Homo sapiens cDNA FLJ25496 fis, clone CBR01585. DQ995344 - Homo sapiens V-ATPase e2 subunit splice variant (ATP6V0E2) mRNA, partial cds, alternatively spliced. AK172725 - Homo sapiens cDNA PSEC0018 fis, clone: NT2RP1000042, moderately similar to VACUOLAR ATP SYNTHASE SUBUNIT H (EC 3.6.1.34). LF362214 - JP 2014500723-A/169717: Polycomb-Associated Non-Coding RNAs. AY037164 - Homo sapiens vacuolar proton-ATPase subunit mRNA, complete cds. MA442702 - JP 2018138019-A/14628: Polycomb-Associated Non-Coding RNAs. MA597791 - JP 2018138019-A/169717: Polycomb-Associated Non-Coding RNAs.