Human Gene CDK5 (uc003wir.2)
  Description: Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 1, mRNA.
RefSeq Summary (NM_004935): This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Transcript (Including UTRs)
   Position: hg19 chr7:150,750,899-150,755,052 Size: 4,154 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr7:150,751,096-150,754,935 Size: 3,840 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:150,750,899-150,755,052)mRNA (may differ from genome)Protein (292 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDK5_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 5; EC=2.7.11.22; AltName: Full=Cell division protein kinase 5; AltName: Full=Serine/threonine-protein kinase PSSALRE; AltName: Full=Tau protein kinase II catalytic subunit; Short=TPKII catalytic subunit;
FUNCTION: Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6- benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4- aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and ATP6V0D1 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and ATP6V0D1 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain- derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration.
SUBUNIT: Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta- catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity).
INTERACTION: Q15078:CDK5R1; NbExp=5; IntAct=EBI-1041567, EBI-746189; P38936:CDKN1A; NbExp=2; IntAct=EBI-1041567, EBI-375077; P46527:CDKN1B; NbExp=4; IntAct=EBI-1041567, EBI-519280; P37231-2:PPARG; NbExp=2; IntAct=EBI-1041567, EBI-781416;
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Co-localizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5.
SUBCELLULAR LOCATION: Isoform 2: Nucleus.
TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.
PTM: Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.
MISCELLANEOUS: Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDK5
CDC HuGE Published Literature: CDK5
Positive Disease Associations: Alzheimer's disease
Related Studies:
  1. Alzheimer's disease
    Alejandro Arias-Vasquez , et al. Journal of neurology 2008 255(5):655-62, Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study., Journal of neurology 2008 255(5):655-62. [PubMed 18350355]

-  MalaCards Disease Associations
  MalaCards Gene Search: CDK5
Diseases sorted by gene-association score: lissencephaly 7 with cerebellar hypoplasia* (969), lissencephaly (24), ischemia (10), aneurysmal bone cysts (9), lissencephaly with cerebellar hypoplasia (7), pachygyria (7), non-syndromic intellectual disability (6), alzheimer disease (6), lateral sclerosis (3), neuroblastoma (3), amyotrophic lateral sclerosis 1 (2), parkinson disease, late-onset (2), syndromic intellectual disability (2), charcot-marie-tooth disease, type 2e (1), dementia, lewy body (1), nervous system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.81 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 726.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.90117-0.555 Picture PostScript Text
3' UTR -86.50197-0.439 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1H4L - X-ray MuPIT 1LFR - Model 1UNG - X-ray MuPIT 1UNH - X-ray MuPIT 1UNL - X-ray MuPIT 3O0G - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q00535
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005176 ErbB-2 class receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008092 cytoskeletal protein binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0030549 acetylcholine receptor activator activity
GO:0043125 ErbB-3 class receptor binding
GO:0046875 ephrin receptor binding
GO:0050321 tau-protein kinase activity
GO:0051879 Hsp90 protein binding
GO:0008017 microtubule binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization
GO:0007049 cell cycle
GO:0007160 cell-matrix adhesion
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007519 skeletal muscle tissue development
GO:0008045 motor neuron axon guidance
GO:0008283 cell proliferation
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009611 response to wounding
GO:0014044 Schwann cell development
GO:0016079 synaptic vesicle exocytosis
GO:0016241 regulation of macroautophagy
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0021695 cerebellar cortex development
GO:0021697 cerebellar cortex formation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0022038 corpus callosum development
GO:0030182 neuron differentiation
GO:0030334 regulation of cell migration
GO:0030517 negative regulation of axon extension
GO:0030866 cortical actin cytoskeleton organization
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0031397 negative regulation of protein ubiquitination
GO:0031914 negative regulation of synaptic plasticity
GO:0032092 positive regulation of protein binding
GO:0032801 receptor catabolic process
GO:0034352 positive regulation of glial cell apoptotic process
GO:0035249 synaptic transmission, glutamatergic
GO:0035418 protein localization to synapse
GO:0042220 response to cocaine
GO:0042501 serine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043113 receptor clustering
GO:0043525 positive regulation of neuron apoptotic process
GO:0045055 regulated exocytosis
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0046777 protein autophosphorylation
GO:0046826 negative regulation of protein export from nucleus
GO:0048148 behavioral response to cocaine
GO:0048167 regulation of synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048511 rhythmic process
GO:0048675 axon extension
GO:0048709 oligodendrocyte differentiation
GO:0048812 neuron projection morphogenesis
GO:0048813 dendrite morphogenesis
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070509 calcium ion import
GO:0071156 regulation of cell cycle arrest
GO:0090314 positive regulation of protein targeting to membrane
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1903076 regulation of protein localization to plasma membrane
GO:1903421 regulation of synaptic vesicle recycling
GO:1904646 cellular response to beta-amyloid
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000273 positive regulation of receptor activity

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098793 presynapse


-  Descriptions from all associated GenBank mRNAs
  L04658 - Homo sapiens gene sequence.
BC005115 - Homo sapiens cyclin-dependent kinase 5, mRNA (cDNA clone MGC:1469 IMAGE:3537202), complete cds.
GQ900934 - Homo sapiens clone HEL-T-46 epididymis secretory sperm binding protein mRNA, complete cds.
AK026533 - Homo sapiens cDNA: FLJ22880 fis, clone KAT03552, highly similar to HSSTHPKE Homo sapiens mRNA PSSALRE for serine/threonine protein kinase.
AY927560 - Homo sapiens mRNA sequence.
X66364 - H.sapiens mRNA PSSALRE for serine/threonine protein kinase.
AY049778 - Homo sapiens cyclin-dependent kinase 5 (CDK5) mRNA, complete cds.
BT006680 - Homo sapiens cyclin-dependent kinase 5 mRNA, complete cds.
DQ411039 - Homo sapiens protein kinase CDK5 splicing variant mRNA, complete cds, alternatively spliced.
KJ905165 - Synthetic construct Homo sapiens clone ccsbBroadEn_14575 CDK5 gene, encodes complete protein.
KJ890884 - Synthetic construct Homo sapiens clone ccsbBroadEn_00278 CDK5 gene, encodes complete protein.
CU674995 - Synthetic construct Homo sapiens gateway clone IMAGE:100016981 5' read CDK5 mRNA.
KU177968 - Homo sapiens cyclin-dependent kinase 5 isoform 1 (CDK5) mRNA, partial cds.
KU177969 - Homo sapiens cyclin-dependent kinase 5 isoform 2 (CDK5) mRNA, partial cds.
AB463550 - Synthetic construct DNA, clone: pF1KB8207, Homo sapiens CDK5 gene for cyclin-dependent kinase 5, without stop codon, in Flexi system.
CR457041 - Homo sapiens full open reading frame cDNA clone RZPDo834B0318D for gene CDK5, cyclin-dependent kinase 5; complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04360 - Axon guidance
hsa05010 - Alzheimer's disease

BioCarta from NCI Cancer Genome Anatomy Project
h_fosbPathway - FOSB gene expression and drug abuse
h_p35alzheimersPathway - Deregulation of CDK5 in Alzheimers Disease
h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
h_rac1Pathway - Rac 1 cell motility signaling pathway
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
h_reelinPathway - Reelin Signaling Pathway
h_Lis1Pathway - Lissencephaly gene (LIS1) in neuronal migration and development
h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors

Reactome (by CSHL, EBI, and GO)

Protein Q00535 (Reactome details) participates in the following event(s):

R-HSA-1013833 Cables link CDK5 and ABL1
R-HSA-8863013 CDK5 binds p25
R-NUL-9032945 Ntrk2 phosohorylates CDK5
R-HSA-399946 Recruitment and activation of Cdk5
R-HSA-9032841 Activated NTRK2 binds CDK5
R-HSA-8863587 CDK5:p25 translocates to the nucleus
R-HSA-180047 CDK5 phosphorylates DARPP-32 on Thr75
R-HSA-9032863 CDK5 phosphorylates NTRK2
R-HSA-9032854 NTRK2 phosphorylates CDK5
R-HSA-8863007 p25-bound CDK5 phosphorylates CDC25B
R-HSA-8863011 p25-bound CDK5 phosphorylates CDC25C
R-HSA-8868260 CDK5:p25 phosphorylates GOLGA2
R-HSA-8868567 CDK5:p25 phosphorylates PRDX1
R-HSA-8868573 CDK5:p25 phosphorylates PRDX2
R-HSA-8868666 CDK5:p25 phosphorylates JUN
R-HSA-8870558 CDK5:p25 phosphorylates FOXO3
R-HSA-6805276 CDK5 phosphorylates TP53
R-HSA-8863014 p25-bound CDK5 phosphorylates CDC25A
R-HSA-8868340 CDK5:p25 phosphorylates lamin B1
R-HSA-8868344 CDK5:p25 phosphorylates lamin A
R-HSA-399951 Phosphorylation of CRMPs by GSK3beta
R-HSA-399944 Phosphorylation of CRMPs by Cdk5
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-9032845 Activated NTRK2 signals through CDK5
R-HSA-109582 Hemostasis
R-HSA-8863678 Neurodegenerative Diseases
R-HSA-180024 DARPP-32 events
R-HSA-373755 Semaphorin interactions
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-1643685 Disease
R-HSA-111885 Opioid Signalling
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-422475 Axon guidance
R-HSA-166520 Signaling by NTRKs
R-HSA-418594 G alpha (i) signalling events
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-1266738 Developmental Biology
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-388396 GPCR downstream signalling
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A1XKG3, CDK5_HUMAN, CDKN5, NM_004935, NP_004926, Q00535
UCSC ID: uc003wir.2
RefSeq Accession: NM_004935
Protein: Q00535 (aka CDK5_HUMAN)
CCDS: CCDS47748.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004935.3
exon count: 12CDS single in 3' UTR: no RNA size: 1211
ORF size: 879CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1958.00frame shift in genome: no % Coverage: 98.51
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 1
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.