Description: Homo sapiens Fas-activated serine/threonine kinase (FASTK), transcript variant 5, mRNA. RefSeq Summary (NM_001258461): The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:150,773,708-150,777,970 Size: 4,263 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr7:150,773,812-150,777,853 Size: 4,042 Coding Exon Count: 10
ID:F8VTW9_HUMAN DESCRIPTION: SubName: Full=Fas-activated serine/threonine kinase; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06743 - FAST kinase-like protein, subdomain 1 PF08368 - FAST kinase-like protein, subdomain 2 PF08373 - RAP domain
ModBase Predicted Comparative 3D Structure on F8VTW9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
