Description: Homo sapiens non-SMC condensin II complex, subunit G2 (NCAPG2), mRNA. RefSeq Summary (NM_017760): This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. Transcript (Including UTRs) Position: hg19 chr7:158,424,003-158,497,520 Size: 73,518 Total Exon Count: 29 Strand: - Coding Region Position: hg19 chr7:158,424,358-158,494,590 Size: 70,233 Coding Exon Count: 27
ID:CNDG2_HUMAN DESCRIPTION: RecName: Full=Condensin-2 complex subunit G2; AltName: Full=Chromosome-associated protein G2; Short=CAP-G2; Short=hCAP-G2; AltName: Full=Leucine zipper protein 5; AltName: Full=Non-SMC condensin II complex subunit G2; FUNCTION: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. SUBUNIT: Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 HEAT repeat. SEQUENCE CAUTION: Sequence=AAH20560.1; Type=Erroneous initiation; Sequence=BAB14219.1; Type=Erroneous initiation; Sequence=BAB14534.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86XI2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.