Human Gene NCAPG2 (uc003wnx.1)
  Description: Homo sapiens non-SMC condensin II complex, subunit G2 (NCAPG2), mRNA.
RefSeq Summary (NM_017760): This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Transcript (Including UTRs)
   Position: hg19 chr7:158,424,003-158,497,520 Size: 73,518 Total Exon Count: 29 Strand: -
Coding Region
   Position: hg19 chr7:158,424,358-158,494,590 Size: 70,233 Coding Exon Count: 27 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:158,424,003-158,497,520)mRNA (may differ from genome)Protein (1143 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CNDG2_HUMAN
DESCRIPTION: RecName: Full=Condensin-2 complex subunit G2; AltName: Full=Chromosome-associated protein G2; Short=CAP-G2; Short=hCAP-G2; AltName: Full=Leucine zipper protein 5; AltName: Full=Non-SMC condensin II complex subunit G2;
FUNCTION: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
SUBUNIT: Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Contains 1 HEAT repeat.
SEQUENCE CAUTION: Sequence=AAH20560.1; Type=Erroneous initiation; Sequence=BAB14219.1; Type=Erroneous initiation; Sequence=BAB14534.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.86 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 89.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.50198-0.407 Picture PostScript Text
3' UTR -79.65355-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR024741 - Condensin2_G2

Pfam Domains:
PF12422 - Condensin II non structural maintenance of chromosomes subunit

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

ModBase Predicted Comparative 3D Structure on Q86XI2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0035064 methylated histone binding

Biological Process:
GO:0001833 inner cell mass cell proliferation
GO:0007049 cell cycle
GO:0030261 chromosome condensation
GO:0051301 cell division

Cellular Component:
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  BC028618 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone IMAGE:4821510), with apparent retained intron.
BC020560 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone MGC:21468 IMAGE:3458938), complete cds.
BC043404 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone MGC:50909 IMAGE:6045248), complete cds.
AK023347 - Homo sapiens cDNA FLJ13285 fis, clone OVARC1001129.
AK092008 - Homo sapiens cDNA FLJ34689 fis, clone MESAN2000815, highly similar to Homo sapiens leucine zipper protein 5 (LUZP5), mRNA.
AX747307 - Sequence 832 from Patent EP1308459.
AK000318 - Homo sapiens cDNA FLJ20311 fis, clone HEP07319.
AK022744 - Homo sapiens cDNA FLJ12682 fis, clone NT2RM4002452.
AK315699 - Homo sapiens cDNA, FLJ96798.
EU832468 - Synthetic construct Homo sapiens clone HAIB:100067497; DKFZo008C0529 non-SMC condensin II complex, subunit G2 protein (NCAPG2) gene, encodes complete protein.
EU832548 - Synthetic construct Homo sapiens clone HAIB:100067577; DKFZo004C0530 non-SMC condensin II complex, subunit G2 protein (NCAPG2) gene, encodes complete protein.
BX537845 - Homo sapiens mRNA; cDNA DKFZp686G2253 (from clone DKFZp686G2253); complete cds.
AK301901 - Homo sapiens cDNA FLJ59780 complete cds, highly similar to Homo sapiens leucine zipper protein 5 (LUZP5), mRNA.
BC005878 - Homo sapiens non-SMC condensin II complex, subunit G2, mRNA (cDNA clone IMAGE:3143004), partial cds.
JD021022 - Sequence 2046 from Patent EP1572962.
AK295057 - Homo sapiens cDNA FLJ54675 complete cds, highly similar to Homo sapiens leucine zipper protein 5 (LUZP5), mRNA.
JD025079 - Sequence 6103 from Patent EP1572962.
JD030032 - Sequence 11056 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86XI2 (Reactome details) participates in the following event(s):

R-HSA-2172666 RB1 binds condensin II
R-HSA-2288097 Condensin II complex binds H4K20me1-containing nucleosomes
R-HSA-2429719 MCPH1 sequesters condensin II
R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3
R-HSA-2294580 PLK1 hyperphosphorylates Condensin II complex
R-HSA-2294590 PLK1 binds phosphorylated condensin II complex
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: A4D228, AX747307, CNDG2_HUMAN, LUZP5, NM_017760, NP_060230, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
UCSC ID: uc003wnx.1
RefSeq Accession: NM_017760
Protein: Q86XI2 (aka CNDG2_HUMAN)
CCDS: CCDS64816.1, CCDS43686.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AX747307.1
exon count: 29CDS single in 3' UTR: no RNA size: 3919
ORF size: 3432CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 7004.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.