Human Gene TACC1 (uc003xme.1)
  Description: Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), transcript variant 2, mRNA.
RefSeq Summary (NM_001122824): This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
Transcript (Including UTRs)
   Position: hg19 chr8:38,614,757-38,688,695 Size: 73,939 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr8:38,614,851-38,688,695 Size: 73,845 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:38,614,757-38,688,695)mRNA (may differ from genome)Protein (145 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGeneCardsGeneNetworkH-INVHGNC
LynxMalacardsMGIPubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TACC1
CDC HuGE Published Literature: TACC1

-  MalaCards Disease Associations
  MalaCards Gene Search: TACC1
Diseases sorted by gene-association score: gliosarcoma* (202), giant cell glioblastoma* (132), breast cancer (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.86 RPKM in Esophagus - Muscularis
Total median expression: 1170.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.4094-0.323 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BX647696 - Homo sapiens mRNA; cDNA DKFZp686K18126 (from clone DKFZp686K18126).
AY072873 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-B (TACC1) mRNA, partial cds; alternatively spliced.
AY072876 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-E (TACC1) mRNA, partial cds; alternatively spliced.
AK304774 - Homo sapiens cDNA FLJ52058 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295071 - Homo sapiens cDNA FLJ50409 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK303596 - Homo sapiens cDNA FLJ52382 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK304507 - Homo sapiens cDNA FLJ56209 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
BC041391 - Homo sapiens transforming, acidic coiled-coil containing protein 1, mRNA (cDNA clone MGC:43967 IMAGE:5276767), complete cds.
JF432777 - Synthetic construct Homo sapiens clone IMAGE:100074021 transforming, acidic coiled-coil containing protein 1 (TACC1) gene, encodes complete protein.
KJ901774 - Synthetic construct Homo sapiens clone ccsbBroadEn_11168 TACC1 gene, encodes complete protein.
AY072874 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-C (TACC1) mRNA, partial cds; alternatively spliced.
AY072875 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-D (TACC1) mRNA, partial cds; alternatively spliced.
AK308849 - Homo sapiens cDNA, FLJ98890.
AK314620 - Homo sapiens cDNA, FLJ95461, highly similar to Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), mRNA.
AF049910 - Homo sapiens TACC1 (TACC1) mRNA, complete cds.
AY177411 - Homo sapiens transforming acidic coiled-coil containing protein 1 short isoform (TACC1) mRNA, complete cds.
AB463317 - Synthetic construct DNA, clone: pF1KB9572, Homo sapiens TACC1 gene for transforming, acidic coiled-coil containing protein 1, without stop codon, in Flexi system.
AK294931 - Homo sapiens cDNA FLJ50512 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295841 - Homo sapiens cDNA FLJ50411 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AB029026 - Homo sapiens mRNA for KIAA1103 protein, partial cds.
AK304725 - Homo sapiens cDNA FLJ52297 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AY039239 - Homo sapiens gastric cancer antigen Ga55 (TACC1) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AY072875
UCSC ID: uc003xme.1
RefSeq Accession: NM_001122824

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY072875.1
exon count: 5CDS single in 3' UTR: no RNA size: 491
ORF size: 435CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 942.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.