Description: Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant 2, mRNA. RefSeq Summary (NM_153831): This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]. Transcript (Including UTRs) Position: hg19 chr8:141,668,481-141,774,522 Size: 106,042 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr8:141,669,565-141,774,450 Size: 104,886 Coding Exon Count: 18
ID:E9PEI4_HUMAN DESCRIPTION: SubName: Full=Focal adhesion kinase 1; CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SIMILARITY: Contains 1 protein kinase domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
hepatocellular carcinoma Okamoto H 2003, PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas., Hepatology (Baltimore, Md). 2003 Nov;38(5):1242-9.
[PubMed 14578863]
Multiple Sclerosis F Weber et al. The pharmacogenomics journal 2012, , The pharmacogenomics journal.
[PubMed 21502966]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF03623 - Focal adhesion targeting region PF07714 - Protein tyrosine kinase
SCOP Domains: 68993 - FAT domain of focal adhesion kinase 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on E9PEI4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
