ID:BOP1_HUMAN DESCRIPTION: RecName: Full=Ribosome biogenesis protein BOP1; AltName: Full=Block of proliferation 1 protein; FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. INTERACTION: O00541:PES1; NbExp=3; IntAct=EBI-1050828, EBI-1053271; Q9GZL7:WDR12; NbExp=3; IntAct=EBI-1050828, EBI-2490660; SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. INDUCTION: By MYC. SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family. SIMILARITY: Contains 7 WD repeats. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BOP1ID44348ch8q22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14137
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000027 ribosomal large subunit assembly GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006364 rRNA processing GO:0008283 cell proliferation GO:0042254 ribosome biogenesis GO:0042273 ribosomal large subunit biogenesis GO:0051726 regulation of cell cycle GO:1901796 regulation of signal transduction by p53 class mediator