Description: Homo sapiens solute carrier family 39 (zinc transporter), member 4 (SLC39A4), transcript variant 1, mRNA. RefSeq Summary (NM_017767): This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr8:145,637,798-145,641,917 Size: 4,120 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr8:145,637,922-145,641,592 Size: 3,671 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P5W5-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK056900 - Homo sapiens cDNA FLJ32338 fis, clone PROST2005919. LF210336 - JP 2014500723-A/17839: Polycomb-Associated Non-Coding RNAs. BC001688 - Homo sapiens solute carrier family 39 (zinc transporter), member 4, mRNA (cDNA clone IMAGE:2990059), partial cds. AK000489 - Homo sapiens cDNA FLJ20482 fis, clone KAT07592. BC033807 - Homo sapiens solute carrier family 39 (zinc transporter), member 4, mRNA (cDNA clone IMAGE:5185763), with apparent retained intron. AK000334 - Homo sapiens cDNA FLJ20327 fis, clone HEP10012. BC062625 - Homo sapiens solute carrier family 39 (zinc transporter), member 4, mRNA (cDNA clone MGC:74741 IMAGE:5203858), complete cds. AK025537 - Homo sapiens cDNA: FLJ21884 fis, clone HEP02863. AK290563 - Homo sapiens cDNA FLJ78154 complete cds, highly similar to Homo sapiens solute carrier family 39 (zinc transporter), member 4 (SLC39A4), transcript variant 2, mRNA. AK000695 - Homo sapiens cDNA FLJ20688 fis, clone KAIA2899. JD412602 - Sequence 393626 from Patent EP1572962. JD412603 - Sequence 393627 from Patent EP1572962. JD174902 - Sequence 155926 from Patent EP1572962. JD280392 - Sequence 261416 from Patent EP1572962. KJ899164 - Synthetic construct Homo sapiens clone ccsbBroadEn_08558 SLC39A4 gene, encodes complete protein. KR711111 - Synthetic construct Homo sapiens clone CCSBHm_00020435 SLC39A4 (SLC39A4) mRNA, encodes complete protein. KR711112 - Synthetic construct Homo sapiens clone CCSBHm_00020443 SLC39A4 (SLC39A4) mRNA, encodes complete protein. KU178707 - Homo sapiens solute carrier family 39 member 4 isoform 1 (SLC39A4) mRNA, partial cds. KU178708 - Homo sapiens solute carrier family 39 member 4 isoform 2 (SLC39A4) mRNA, partial cds, alternatively spliced. LF337129 - JP 2014500723-A/144632: Polycomb-Associated Non-Coding RNAs. LF337130 - JP 2014500723-A/144633: Polycomb-Associated Non-Coding RNAs. JD077345 - Sequence 58369 from Patent EP1572962. JD324979 - Sequence 306003 from Patent EP1572962. JD389094 - Sequence 370118 from Patent EP1572962. JD375231 - Sequence 356255 from Patent EP1572962. JD051599 - Sequence 32623 from Patent EP1572962. JD255288 - Sequence 236312 from Patent EP1572962. JD335148 - Sequence 316172 from Patent EP1572962. JD324832 - Sequence 305856 from Patent EP1572962. JD308019 - Sequence 289043 from Patent EP1572962. JD037332 - Sequence 18356 from Patent EP1572962. MA445913 - JP 2018138019-A/17839: Polycomb-Associated Non-Coding RNAs. MA572706 - JP 2018138019-A/144632: Polycomb-Associated Non-Coding RNAs. MA572707 - JP 2018138019-A/144633: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6P5W5 (Reactome details) participates in the following event(s):
R-HSA-442422 SLC39A1-4 transports Zn2+ from extracellular region to cytosol R-HSA-442380 Zinc influx into cells by the SLC39 gene family R-HSA-435354 Zinc transporters R-HSA-425410 Metal ion SLC transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules