Description: Homo sapiens interferon, alpha 1 (IFNA1), mRNA. RefSeq Summary (NM_024013): The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr9:21,440,453-21,441,315 Size: 863 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr9:21,440,507-21,441,076 Size: 570 Coding Exon Count: 1
ID:IFNA1_HUMAN DESCRIPTION: RecName: Full=Interferon alpha-1/13; Short=IFN-alpha-1/13; AltName: Full=Interferon alpha-D; Short=LeIF D; Flags: Precursor; FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. SUBCELLULAR LOCATION: Secreted. POLYMORPHISM: Two forms exist; alpha-1a (shown here) and alpha-1b. MISCELLANEOUS: Interferons alpha-1 and alpha-13 have identical protein sequences. SIMILARITY: Belongs to the alpha/beta interferon family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ifna1/";
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): IFNA1 CDC HuGE Published Literature: IFNA1 Positive Disease Associations: lupus erythematosus
, malaria Related Studies:
lupus erythematosus Nakashima, H. et al. 2005, Association between IFNA genotype and the risk of systemic lupus erythematosus, Clinical rheumatology. 2005 Feb;24(1):38-40.
[PubMed 15674657]
The results showed that no IFN-alpha genotype was significantly associated with the risk of SLE.
lupus erythematosus Nakashima, H. et al. 2004, Association between IFNA genotype and the risk of systemic lupus erythematosus, Clinical rheumatology. 2005 Feb;24(1):38-40.
[PubMed 15674657]
We analyzed the association between IFN-alpha genotype and the risk of SLE to clarify whether IFN-alpha plays a central role in susceptibility to SLE. The results showed that no IFN-alpha genotype was significantly associated with the risk of SLE.
malaria Aucan, C. et al. 2003, Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia., Genes and immunity. 2003 Jun;4(4):275-82.
[PubMed 12761564]
These data suggest a role for the type I interferon pathway in resistance to cerebral malaria.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01562
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_inflamPathway - Cytokines and Inflammatory Response h_il1rPathway - Signal transduction through IL1R h_cytokinePathway - Cytokine Network h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development h_ifnaPathway - IFN alpha signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein P01562 (Reactome details) participates in the following event(s):
US Server
