Human Gene RNF38 (uc003zzi.3)
  Description: Homo sapiens ring finger protein 38 (RNF38), transcript variant 3, mRNA.
RefSeq Summary (NM_194329): This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Transcript (Including UTRs)
   Position: hg19 chr9:36,336,399-36,400,296 Size: 63,898 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr9:36,339,749-36,400,105 Size: 60,357 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:36,336,399-36,400,296)mRNA (may differ from genome)Protein (465 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.79 RPKM in Testis
Total median expression: 494.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.90191-0.287 Picture PostScript Text
3' UTR -862.483350-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF12678 - RING-H2 zinc finger domain
PF13445 - RING-type zinc-finger
PF13639 - Ring finger domain
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF17123 - RING-like zinc finger

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q9H0F5-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AK025466 - Homo sapiens cDNA: FLJ21813 fis, clone HEP01047.
AK024996 - Homo sapiens cDNA: FLJ21343 fis, clone COL02679.
AF394047 - Homo sapiens RING finger protein 38 (RNF38) mRNA, complete cds.
JD295328 - Sequence 276352 from Patent EP1572962.
JD347828 - Sequence 328852 from Patent EP1572962.
JD337151 - Sequence 318175 from Patent EP1572962.
JD234301 - Sequence 215325 from Patent EP1572962.
JD114039 - Sequence 95063 from Patent EP1572962.
JD347473 - Sequence 328497 from Patent EP1572962.
JD312431 - Sequence 293455 from Patent EP1572962.
JD058976 - Sequence 40000 from Patent EP1572962.
JD543625 - Sequence 524649 from Patent EP1572962.
JD269841 - Sequence 250865 from Patent EP1572962.
JD356888 - Sequence 337912 from Patent EP1572962.
JD501180 - Sequence 482204 from Patent EP1572962.
JD505024 - Sequence 486048 from Patent EP1572962.
JD449724 - Sequence 430748 from Patent EP1572962.
JD260034 - Sequence 241058 from Patent EP1572962.
JD512322 - Sequence 493346 from Patent EP1572962.
JD233546 - Sequence 214570 from Patent EP1572962.
JD299196 - Sequence 280220 from Patent EP1572962.
JD261403 - Sequence 242427 from Patent EP1572962.
JD555006 - Sequence 536030 from Patent EP1572962.
JD272375 - Sequence 253399 from Patent EP1572962.
JD233799 - Sequence 214823 from Patent EP1572962.
JD284035 - Sequence 265059 from Patent EP1572962.
JD509783 - Sequence 490807 from Patent EP1572962.
JD501878 - Sequence 482902 from Patent EP1572962.
JD311013 - Sequence 292037 from Patent EP1572962.
AL136817 - Homo sapiens mRNA; cDNA DKFZp434A0926 (from clone DKFZp434A0926).
AK097653 - Homo sapiens cDNA FLJ40334 fis, clone TESTI2031919.
AK093480 - Homo sapiens cDNA FLJ36161 fis, clone TESTI2025911, highly similar to RING finger protein 38.
AX748155 - Sequence 1680 from Patent EP1308459.
BC033786 - Homo sapiens ring finger protein 38, mRNA (cDNA clone MGC:44972 IMAGE:5166325), complete cds.
KJ895667 - Synthetic construct Homo sapiens clone ccsbBroadEn_05061 RNF38 gene, encodes complete protein.
DQ895235 - Synthetic construct Homo sapiens clone IMAGE:100009695; FLH182626.01L; RZPDo839A05139D ring finger protein 38 (RNF38) gene, encodes complete protein.
EU176239 - Synthetic construct Homo sapiens clone IMAGE:100006425; FLH182630.01X; RZPDo839A05140D ring finger protein 38 (RNF38) gene, encodes complete protein.
AM392682 - Synthetic construct Homo sapiens clone IMAGE:100002374 for hypothetical protein (RNF38 gene).
JD364812 - Sequence 345836 from Patent EP1572962.
JD516918 - Sequence 497942 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_194329, NP_919313, Q9H0F5-2
UCSC ID: uc003zzi.3
RefSeq Accession: NM_194329
Protein: Q9H0F5-2, splice isoform of Q9H0F5 CCDS: CCDS6604.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_194329.2
exon count: 11CDS single in 3' UTR: no RNA size: 4951
ORF size: 1398CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2963.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.