Description: Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant c, mRNA. RefSeq Summary (NM_001018066): This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Transcript (Including UTRs) Position: hg19 chr9:87,283,466-87,573,178 Size: 289,713 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chr9:87,285,664-87,570,516 Size: 284,853 Coding Exon Count: 15
anorexia nervosa; bulimia Ribases, M. et al. 2005, Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index., Molecular psychiatry. 2005 Sep;10(9):851-60.
[PubMed 15838534]
Our data support a contribution of NTRK2 to the genetic susceptibility of ED, mainly ANP, and ED-related phenotypic traits, such as Harm avoidance and minimum body mass index
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48726 - Immunoglobulin 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q16620-6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
