Description: Homo sapiens ninjurin 1 (NINJ1), mRNA. RefSeq Summary (NM_004148): The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]. Transcript (Including UTRs) Position: hg19 chr9:95,883,771-95,896,570 Size: 12,800 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr9:95,887,190-95,896,499 Size: 9,310 Coding Exon Count: 3
ID:NINJ1_HUMAN DESCRIPTION: RecName: Full=Ninjurin-1; AltName: Full=Nerve injury-induced protein 1; FUNCTION: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin. INDUCTION: By nerve injury both in dorsal root ganglion neurons and in Schwann cells. SIMILARITY: Belongs to the ninjurin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92982
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.