Human Gene TRIM14 (uc004ayd.2)
Description: Homo sapiens tripartite motif containing 14 (TRIM14), transcript variant 3, mRNA.
Transcript (Including UTRs)
Position: hg19 chr9:100,831,569-100,881,488 Size: 49,920 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr9:100,849,752-100,881,470 Size: 31,719 Coding Exon Count: 6
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TRI14_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 14;
FUNCTION: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner (By similarity).SUBUNIT: Interacts with SPI1 (By similarity).TISSUE SPECIFICITY: Highest expression in liver; undetectable in skeletal muscle.INDUCTION: By interferons alpha and gamma.DOMAIN: The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation (By similarity).SIMILARITY: Belongs to the TRIM/RBCC family.SIMILARITY: Contains 1 B box-type zinc finger.SIMILARITY: Contains 1 B30.2/SPRY domain.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TRIM14
CDC HuGE Published Literature: TRIM14
Positive Disease Associations: Body Height
Related Studies: Body Height , , .
[PubMed 0 ]
MalaCards Disease Associations
MalaCards Gene Search: TRIM14
Diseases sorted by gene-association score: bone cancer (2)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
Pfam Domains: PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF13765 - SPRY-associated domain
SCOP Domains: 57845 - B-box zinc-binding domain
ModBase Predicted Comparative 3D Structure on Q14142
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC006333 - Homo sapiens tripartite motif-containing 14, mRNA (cDNA clone MGC:12564 IMAGE:4299815), complete cds.LF385385 - JP 2014500723-A/192888: Polycomb-Associated Non-Coding RNAs.JD117235 - Sequence 98259 from Patent EP1572962.JD117234 - Sequence 98258 from Patent EP1572962.JD366435 - Sequence 347459 from Patent EP1572962.JD366436 - Sequence 347460 from Patent EP1572962.JD534809 - Sequence 515833 from Patent EP1572962.JD292570 - Sequence 273594 from Patent EP1572962.JD155866 - Sequence 136890 from Patent EP1572962.JD092093 - Sequence 73117 from Patent EP1572962.JD059727 - Sequence 40751 from Patent EP1572962.JD105897 - Sequence 86921 from Patent EP1572962.JD517584 - Sequence 498608 from Patent EP1572962.JD534810 - Sequence 515834 from Patent EP1572962.JD155867 - Sequence 136891 from Patent EP1572962.JD199907 - Sequence 180931 from Patent EP1572962.JD534811 - Sequence 515835 from Patent EP1572962.JD155868 - Sequence 136892 from Patent EP1572962.JD059728 - Sequence 40752 from Patent EP1572962.JD149380 - Sequence 130404 from Patent EP1572962.JD125823 - Sequence 106847 from Patent EP1572962.JD055312 - Sequence 36336 from Patent EP1572962.JD306446 - Sequence 287470 from Patent EP1572962.JD169813 - Sequence 150837 from Patent EP1572962.JD529506 - Sequence 510530 from Patent EP1572962.JD430370 - Sequence 411394 from Patent EP1572962.JD395570 - Sequence 376594 from Patent EP1572962.JD125822 - Sequence 106846 from Patent EP1572962.JD084412 - Sequence 65436 from Patent EP1572962.JD169812 - Sequence 150836 from Patent EP1572962.JD514903 - Sequence 495927 from Patent EP1572962.JD324430 - Sequence 305454 from Patent EP1572962.JD240761 - Sequence 221785 from Patent EP1572962.JD238532 - Sequence 219556 from Patent EP1572962.JD135942 - Sequence 116966 from Patent EP1572962.JD090427 - Sequence 71451 from Patent EP1572962.JD208378 - Sequence 189402 from Patent EP1572962.JD537351 - Sequence 518375 from Patent EP1572962.JD481475 - Sequence 462499 from Patent EP1572962.JD286025 - Sequence 267049 from Patent EP1572962.JD246964 - Sequence 227988 from Patent EP1572962.JD429245 - Sequence 410269 from Patent EP1572962.JD084229 - Sequence 65253 from Patent EP1572962.JD246963 - Sequence 227987 from Patent EP1572962.JD413414 - Sequence 394438 from Patent EP1572962.JD182686 - Sequence 163710 from Patent EP1572962.JD198113 - Sequence 179137 from Patent EP1572962.JD206738 - Sequence 187762 from Patent EP1572962.JD246962 - Sequence 227986 from Patent EP1572962.JD413413 - Sequence 394437 from Patent EP1572962.JD198112 - Sequence 179136 from Patent EP1572962.JD212723 - Sequence 193747 from Patent EP1572962.JD542745 - Sequence 523769 from Patent EP1572962.JD363019 - Sequence 344043 from Patent EP1572962.JD248624 - Sequence 229648 from Patent EP1572962.JD260764 - Sequence 241788 from Patent EP1572962.JD424583 - Sequence 405607 from Patent EP1572962.AK097480 - Homo sapiens cDNA FLJ40161 fis, clone TESTI2015710.AF220130 - Homo sapiens tripartite motif protein TRIM14 alpha (TRIM14) mRNA, complete cds; alternatively spliced.AF220131 - Homo sapiens tripartite motif protein TRIM14 beta (TRIM14) mRNA, complete cds; alternatively spliced.D50919 - Homo sapiens mRNA for KIAA0129 gene, complete cds.JD143743 - Sequence 124767 from Patent EP1572962.AK316464 - Homo sapiens cDNA, FLJ79363 complete cds, highly similar to Tripartite motif-containing protein 14.AK055833 - Homo sapiens cDNA FLJ31271 fis, clone KIDNE2006149, weakly similar to Xenopus laevis RING finger protein mRNA.AK303366 - Homo sapiens cDNA FLJ55267 complete cds, highly similar to Tripartite motif-containing protein 14.AK292825 - Homo sapiens cDNA FLJ75477 complete cds, highly similar to Homo sapiens tripartite motif-containing 14 (TRIM14), transcript variant 3, mRNA.DQ893293 - Synthetic construct clone IMAGE:100005923; FLH196222.01X; RZPDo839F11154D tripartite motif-containing 14 (TRIM14) gene, encodes complete protein.DQ896623 - Synthetic construct Homo sapiens clone IMAGE:100011083; FLH196218.01L; RZPDo839F11153D tripartite motif-containing 14 (TRIM14) gene, encodes complete protein.AB529155 - Synthetic construct DNA, clone: pF1KA0129, Homo sapiens TRIM14 gene for tripartite motif-containing protein 14, without stop codon, in Flexi system.LF206454 - JP 2014500723-A/13957: Polycomb-Associated Non-Coding RNAs.MA620962 - JP 2018138019-A/192888: Polycomb-Associated Non-Coding RNAs.MA442031 - JP 2018138019-A/13957: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A8K9W0, E7EQC4, F8W956, KIAA0129, NM_033220, NP_150089, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020, TRI14_HUMANUCSC ID: uc004ayd.2RefSeq Accession: NM_033220
Protein: Q14142
(aka TRI14_HUMAN or TM14_HUMAN)
CCDS: CCDS6734.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_033220.1
exon count:
7 CDS single in 3' UTR:
no
RNA size:
1789
ORF size:
1329 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2854.00 frame shift in genome:
no
% Coverage:
99.27
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.