Human Gene TRIM14 (uc004ayd.2)
  Description: Homo sapiens tripartite motif containing 14 (TRIM14), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:100,831,569-100,881,488 Size: 49,920 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr9:100,849,752-100,881,470 Size: 31,719 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:100,831,569-100,881,488)mRNA (may differ from genome)Protein (442 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIneXtProt
PubMedReactomeTreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TRI14_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 14;
FUNCTION: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner (By similarity).
SUBUNIT: Interacts with SPI1 (By similarity).
TISSUE SPECIFICITY: Highest expression in liver; undetectable in skeletal muscle.
INDUCTION: By interferons alpha and gamma.
DOMAIN: The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation (By similarity).
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TRIM14
CDC HuGE Published Literature: TRIM14
Positive Disease Associations: Body Height
Related Studies:
  1. Body Height
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM14
Diseases sorted by gene-association score: bone cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.89 RPKM in Spleen
Total median expression: 245.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00180.000 Picture PostScript Text
3' UTR -164.04429-0.382 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box

Pfam Domains:
PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF13765 - SPRY-associated domain

SCOP Domains:
57845 - B-box zinc-binding domain

ModBase Predicted Comparative 3D Structure on Q14142
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0002376 immune system process
GO:0032897 negative regulation of viral transcription
GO:0045087 innate immune response
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC006333 - Homo sapiens tripartite motif-containing 14, mRNA (cDNA clone MGC:12564 IMAGE:4299815), complete cds.
LF385385 - JP 2014500723-A/192888: Polycomb-Associated Non-Coding RNAs.
JD117235 - Sequence 98259 from Patent EP1572962.
JD117234 - Sequence 98258 from Patent EP1572962.
JD366435 - Sequence 347459 from Patent EP1572962.
JD366436 - Sequence 347460 from Patent EP1572962.
JD534809 - Sequence 515833 from Patent EP1572962.
JD292570 - Sequence 273594 from Patent EP1572962.
JD155866 - Sequence 136890 from Patent EP1572962.
JD092093 - Sequence 73117 from Patent EP1572962.
JD059727 - Sequence 40751 from Patent EP1572962.
JD105897 - Sequence 86921 from Patent EP1572962.
JD517584 - Sequence 498608 from Patent EP1572962.
JD534810 - Sequence 515834 from Patent EP1572962.
JD155867 - Sequence 136891 from Patent EP1572962.
JD199907 - Sequence 180931 from Patent EP1572962.
JD534811 - Sequence 515835 from Patent EP1572962.
JD155868 - Sequence 136892 from Patent EP1572962.
JD059728 - Sequence 40752 from Patent EP1572962.
JD149380 - Sequence 130404 from Patent EP1572962.
JD125823 - Sequence 106847 from Patent EP1572962.
JD055312 - Sequence 36336 from Patent EP1572962.
JD306446 - Sequence 287470 from Patent EP1572962.
JD169813 - Sequence 150837 from Patent EP1572962.
JD529506 - Sequence 510530 from Patent EP1572962.
JD430370 - Sequence 411394 from Patent EP1572962.
JD395570 - Sequence 376594 from Patent EP1572962.
JD125822 - Sequence 106846 from Patent EP1572962.
JD084412 - Sequence 65436 from Patent EP1572962.
JD169812 - Sequence 150836 from Patent EP1572962.
JD514903 - Sequence 495927 from Patent EP1572962.
JD324430 - Sequence 305454 from Patent EP1572962.
JD240761 - Sequence 221785 from Patent EP1572962.
JD238532 - Sequence 219556 from Patent EP1572962.
JD135942 - Sequence 116966 from Patent EP1572962.
JD090427 - Sequence 71451 from Patent EP1572962.
JD208378 - Sequence 189402 from Patent EP1572962.
JD537351 - Sequence 518375 from Patent EP1572962.
JD481475 - Sequence 462499 from Patent EP1572962.
JD286025 - Sequence 267049 from Patent EP1572962.
JD246964 - Sequence 227988 from Patent EP1572962.
JD429245 - Sequence 410269 from Patent EP1572962.
JD084229 - Sequence 65253 from Patent EP1572962.
JD246963 - Sequence 227987 from Patent EP1572962.
JD413414 - Sequence 394438 from Patent EP1572962.
JD182686 - Sequence 163710 from Patent EP1572962.
JD198113 - Sequence 179137 from Patent EP1572962.
JD206738 - Sequence 187762 from Patent EP1572962.
JD246962 - Sequence 227986 from Patent EP1572962.
JD413413 - Sequence 394437 from Patent EP1572962.
JD198112 - Sequence 179136 from Patent EP1572962.
JD212723 - Sequence 193747 from Patent EP1572962.
JD542745 - Sequence 523769 from Patent EP1572962.
JD363019 - Sequence 344043 from Patent EP1572962.
JD248624 - Sequence 229648 from Patent EP1572962.
JD260764 - Sequence 241788 from Patent EP1572962.
JD424583 - Sequence 405607 from Patent EP1572962.
AK097480 - Homo sapiens cDNA FLJ40161 fis, clone TESTI2015710.
AF220130 - Homo sapiens tripartite motif protein TRIM14 alpha (TRIM14) mRNA, complete cds; alternatively spliced.
AF220131 - Homo sapiens tripartite motif protein TRIM14 beta (TRIM14) mRNA, complete cds; alternatively spliced.
D50919 - Homo sapiens mRNA for KIAA0129 gene, complete cds.
JD143743 - Sequence 124767 from Patent EP1572962.
AK316464 - Homo sapiens cDNA, FLJ79363 complete cds, highly similar to Tripartite motif-containing protein 14.
AK055833 - Homo sapiens cDNA FLJ31271 fis, clone KIDNE2006149, weakly similar to Xenopus laevis RING finger protein mRNA.
AK303366 - Homo sapiens cDNA FLJ55267 complete cds, highly similar to Tripartite motif-containing protein 14.
AK292825 - Homo sapiens cDNA FLJ75477 complete cds, highly similar to Homo sapiens tripartite motif-containing 14 (TRIM14), transcript variant 3, mRNA.
DQ893293 - Synthetic construct clone IMAGE:100005923; FLH196222.01X; RZPDo839F11154D tripartite motif-containing 14 (TRIM14) gene, encodes complete protein.
DQ896623 - Synthetic construct Homo sapiens clone IMAGE:100011083; FLH196218.01L; RZPDo839F11153D tripartite motif-containing 14 (TRIM14) gene, encodes complete protein.
AB529155 - Synthetic construct DNA, clone: pF1KA0129, Homo sapiens TRIM14 gene for tripartite motif-containing protein 14, without stop codon, in Flexi system.
LF206454 - JP 2014500723-A/13957: Polycomb-Associated Non-Coding RNAs.
MA620962 - JP 2018138019-A/192888: Polycomb-Associated Non-Coding RNAs.
MA442031 - JP 2018138019-A/13957: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14142 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9W0, E7EQC4, F8W956, KIAA0129, NM_033220, NP_150089, Q14142, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020, TRI14_HUMAN
UCSC ID: uc004ayd.2
RefSeq Accession: NM_033220
Protein: Q14142 (aka TRI14_HUMAN or TM14_HUMAN)
CCDS: CCDS6734.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_033220.1
exon count: 7CDS single in 3' UTR: no RNA size: 1789
ORF size: 1329CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2854.00frame shift in genome: no % Coverage: 99.27
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.