Human Gene PTGS1 (uc004bmf.2)
Description: Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1), transcript variant 2, mRNA.
RefSeq Summary (NM_080591): This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
Position: hg19 chr9:125,133,284-125,157,982 Size: 24,699 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr9:125,133,364-125,154,823 Size: 21,460 Coding Exon Count: 11
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PTGS1
CDC HuGE Published Literature: PTGS1
Positive Disease Associations: Body Weight
, Cardiovascular Diseases
, colorectal cancer; colon polyps
, Hypertension/complications*
, Stroke
Related Studies: Body Weight , , .
[PubMed 0 ]
Cardiovascular Diseases J Helmersson , et al. Prostaglandins, leukotrienes, and essential fatty acids 2009 80(1):51-6, A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease., Prostaglandins, leukotrienes, and essential fatty acids 2009 80(1):51-6.
[PubMed 19091535 ]
colorectal cancer; colon polyps Ulrich, C. M. et al. 2004, Polymorphisms in PTGS1 (=COX-1) and Risk of Colorectal Polyps, Cancer epidemiology, biomarkers & prevention. 2004 May;13(5):889-93.
[PubMed 15159324 ]
To our knowledge, this study represents the first investigation of polymorphisms in PTGS1 and risk of colorectal polyps. The L15-L16del variant allele may result in an increased risk of colorectal adenomas, whereas P17L may be relevant to the pharmacogenetics of aspirin. These preliminary findings require confirmation in larger studies of colorectal neoplasia.
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MalaCards Disease Associations
MalaCards Gene Search: PTGS1
Diseases sorted by gene-association score: chronic cystitis (12), gastric ulcer (11), urticaria (10), stomach disease (8), ovarian epithelial cancer (8), angioedema (7), familial adenomatous polyposis (7), kidney papillary necrosis (7), dyspepsia (6), active peptic ulcer disease (6), gastroesophageal reflux (6), antenatal bartter syndrome (6), pulmonary disease, chronic obstructive (6), morphine dependence (5), ureteral obstruction (5), hydrops, lactic acidosis, and sideroblastic anemia (5), osteoarthritis (4), colorectal cancer (4), rheumatic disease (2), myocardial infarction (2), autoinflammation, lipodystrophy, and dermatosis syndrome (2)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00008 - EGF-like domain
PF03098 - Animal haem peroxidase
SCOP Domains: 48113 - Heme-dependent peroxidases
57196 - EGF/Laminin
ModBase Predicted Comparative 3D Structure on P23219-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF211804 - JP 2014500723-A/19307: Polycomb-Associated Non-Coding RNAs.AK308222 - Homo sapiens cDNA, FLJ98170.AK295221 - Homo sapiens cDNA FLJ61263 complete cds, highly similar to Prostaglandin G/H synthase 1 precursor (EC 1.14.99.1).LF205668 - JP 2014500723-A/13171: Polycomb-Associated Non-Coding RNAs.JD214692 - Sequence 195716 from Patent EP1572962.JD170654 - Sequence 151678 from Patent EP1572962.BC029840 - Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), mRNA (cDNA clone MGC:34214 IMAGE:5174923), complete cds.AK290022 - Homo sapiens cDNA FLJ77449 complete cds, highly similar to Human prostaglandin endoperoxide synthase mRNA.M59979 - Human prostaglandin endoperoxide synthase mRNA, complete cds.AB590429 - Synthetic construct DNA, clone: pFN21AE1402, Homo sapiens PTGS1 gene for prostaglandin-endoperoxide synthase 1, without stop codon, in Flexi system.JD456074 - Sequence 437098 from Patent EP1572962.DQ180740 - Homo sapiens cyclooxygenase 1b1 mRNA, complete cds, alternatively spliced.DQ180741 - Homo sapiens cyclooxygenase 1b2 mRNA, complete cds, alternatively spliced.DQ180742 - Homo sapiens cyclooxygenase 1b3 mRNA, complete cds, alternatively spliced.S78220 - prostaglandin endoperoxide synthase [human, platelets, mRNA, 1812 nt].S36219 - prostaglandin G/H synthase {alternative splicing product} [human, lung fibroblast, clone HCO-T9, mRNA, 2324 nt].S36271 - prostaglandin G/H synthase [human, lung fibroblast, mRNA, 2435 nt].DQ892441 - Synthetic construct clone IMAGE:100005071; FLH186345.01X; RZPDo839D0771D prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1) gene, encodes complete protein.DQ895652 - Synthetic construct Homo sapiens clone IMAGE:100010112; FLH186341.01L; RZPDo839D0761D prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1) gene, encodes complete protein.AK304403 - Homo sapiens cDNA FLJ53280 complete cds, highly similar to Prostaglandin G/H synthase 1 precursor (EC 1.14.99.1).LF347015 - JP 2014500723-A/154518: Polycomb-Associated Non-Coding RNAs.LF347016 - JP 2014500723-A/154519: Polycomb-Associated Non-Coding RNAs.LF347018 - JP 2014500723-A/154521: Polycomb-Associated Non-Coding RNAs.DL491511 - Novel nucleic acids.DL490120 - Novel nucleic acids.LF347019 - JP 2014500723-A/154522: Polycomb-Associated Non-Coding RNAs.LF347021 - JP 2014500723-A/154524: Polycomb-Associated Non-Coding RNAs.LF347022 - JP 2014500723-A/154525: Polycomb-Associated Non-Coding RNAs.U63846 - Human cyclooxygenase-1 (PTSG1) mRNA, partial cds.JD073437 - Sequence 54461 from Patent EP1572962.JD483955 - Sequence 464979 from Patent EP1572962.DL492176 - Novel nucleic acids.LF347023 - JP 2014500723-A/154526: Polycomb-Associated Non-Coding RNAs.JD501168 - Sequence 482192 from Patent EP1572962.JD228202 - Sequence 209226 from Patent EP1572962.JD245012 - Sequence 226036 from Patent EP1572962.LF347024 - JP 2014500723-A/154527: Polycomb-Associated Non-Coding RNAs.JD295012 - Sequence 276036 from Patent EP1572962.JD251854 - Sequence 232878 from Patent EP1572962.JD063296 - Sequence 44320 from Patent EP1572962.JD048921 - Sequence 29945 from Patent EP1572962.JD269138 - Sequence 250162 from Patent EP1572962.JD193763 - Sequence 174787 from Patent EP1572962.JD111820 - Sequence 92844 from Patent EP1572962.JD480269 - Sequence 461293 from Patent EP1572962.JD466461 - Sequence 447485 from Patent EP1572962.JD425789 - Sequence 406813 from Patent EP1572962.JD278324 - Sequence 259348 from Patent EP1572962.JD381701 - Sequence 362725 from Patent EP1572962.JD224804 - Sequence 205828 from Patent EP1572962.JD095795 - Sequence 76819 from Patent EP1572962.JD321511 - Sequence 302535 from Patent EP1572962.JD561543 - Sequence 542567 from Patent EP1572962.JD554207 - Sequence 535231 from Patent EP1572962.JD136619 - Sequence 117643 from Patent EP1572962.JD491544 - Sequence 472568 from Patent EP1572962.JD359399 - Sequence 340423 from Patent EP1572962.JD244181 - Sequence 225205 from Patent EP1572962.JD040261 - Sequence 21285 from Patent EP1572962.JD103100 - Sequence 84124 from Patent EP1572962.JD063962 - Sequence 44986 from Patent EP1572962.JD280720 - Sequence 261744 from Patent EP1572962.JD241763 - Sequence 222787 from Patent EP1572962.JD114909 - Sequence 95933 from Patent EP1572962.JD565718 - Sequence 546742 from Patent EP1572962.JD514737 - Sequence 495761 from Patent EP1572962.AJ420464 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1672820.JD289354 - Sequence 270378 from Patent EP1572962.JD403431 - Sequence 384455 from Patent EP1572962.JD237551 - Sequence 218575 from Patent EP1572962.JD545779 - Sequence 526803 from Patent EP1572962.JD271623 - Sequence 252647 from Patent EP1572962.JD358138 - Sequence 339162 from Patent EP1572962.JD186635 - Sequence 167659 from Patent EP1572962.JD286361 - Sequence 267385 from Patent EP1572962.JD285146 - Sequence 266170 from Patent EP1572962.JD402001 - Sequence 383025 from Patent EP1572962.AF129755 - Homo sapiens prostaglandin endoperoxide H synthase-1 mRNA, partial 3' untranslated region.JD084856 - Sequence 65880 from Patent EP1572962.JD403683 - Sequence 384707 from Patent EP1572962.JD296464 - Sequence 277488 from Patent EP1572962.JD479976 - Sequence 461000 from Patent EP1572962.JD274107 - Sequence 255131 from Patent EP1572962.JD064878 - Sequence 45902 from Patent EP1572962.JD471478 - Sequence 452502 from Patent EP1572962.AF086438 - Homo sapiens full length insert cDNA clone ZD80G11.JD319834 - Sequence 300858 from Patent EP1572962.JD214064 - Sequence 195088 from Patent EP1572962.JD202198 - Sequence 183222 from Patent EP1572962.JD333579 - Sequence 314603 from Patent EP1572962.JD364038 - Sequence 345062 from Patent EP1572962.JD300708 - Sequence 281732 from Patent EP1572962.JD284376 - Sequence 265400 from Patent EP1572962.JD183380 - Sequence 164404 from Patent EP1572962.JD037762 - Sequence 18786 from Patent EP1572962.JD455998 - Sequence 437022 from Patent EP1572962.JD137883 - Sequence 118907 from Patent EP1572962.JD267045 - Sequence 248069 from Patent EP1572962.MA582592 - JP 2018138019-A/154518: Polycomb-Associated Non-Coding RNAs.MA582593 - JP 2018138019-A/154519: Polycomb-Associated Non-Coding RNAs.MA582595 - JP 2018138019-A/154521: Polycomb-Associated Non-Coding RNAs.MA582596 - JP 2018138019-A/154522: Polycomb-Associated Non-Coding RNAs.MA582598 - JP 2018138019-A/154524: Polycomb-Associated Non-Coding RNAs.MA582599 - JP 2018138019-A/154525: Polycomb-Associated Non-Coding RNAs.MA582600 - JP 2018138019-A/154526: Polycomb-Associated Non-Coding RNAs.MA582601 - JP 2018138019-A/154527: Polycomb-Associated Non-Coding RNAs.MA447381 - JP 2018138019-A/19307: Polycomb-Associated Non-Coding RNAs.MA441245 - JP 2018138019-A/13171: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: COX1, NM_080591, NP_001258296, P23219-2, uc004bmf.1UCSC ID: uc004bmf.2RefSeq Accession: NM_080591
Protein: P23219-2 , splice isoform of P23219
CCDS: CCDS6843.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_080591.2
exon count:
11 CDS single in 3' UTR:
no
RNA size:
4934
ORF size:
1689 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3498.00 frame shift in genome:
no
% Coverage:
99.88
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.