Human Gene ZBTB6 (uc004bnh.4)
  Description: Homo sapiens zinc finger and BTB domain containing 6 (ZBTB6), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:125,670,335-125,675,607 Size: 5,273 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr9:125,673,077-125,674,351 Size: 1,275 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:125,670,335-125,675,607)mRNA (may differ from genome)Protein (424 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZBTB6_HUMAN
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 6; AltName: Full=Zinc finger protein 482; AltName: Full=Zinc finger protein with interaction domain;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Widely expressed with highest levels in brain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 4 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZBTB6
Diseases sorted by gene-association score: myasthenic syndrome, congenital, 5 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.73 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 120.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.1087-0.266 Picture PostScript Text
3' UTR -639.622742-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger

SCOP Domains:
54695 - POZ domain
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q15916
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  LF205680 - JP 2014500723-A/13183: Polycomb-Associated Non-Coding RNAs.
BC037282 - Homo sapiens zinc finger and BTB domain containing 6, mRNA (cDNA clone MGC:33077 IMAGE:5266759), complete cds.
AK098650 - Homo sapiens cDNA FLJ25784 fis, clone TST06730.
JD087823 - Sequence 68847 from Patent EP1572962.
LF347068 - JP 2014500723-A/154571: Polycomb-Associated Non-Coding RNAs.
JD555393 - Sequence 536417 from Patent EP1572962.
JD053168 - Sequence 34192 from Patent EP1572962.
LF347069 - JP 2014500723-A/154572: Polycomb-Associated Non-Coding RNAs.
X82018 - H.sapiens mRNA for ZID protein.
JD062299 - Sequence 43323 from Patent EP1572962.
JD438710 - Sequence 419734 from Patent EP1572962.
JD043071 - Sequence 24095 from Patent EP1572962.
JD500657 - Sequence 481681 from Patent EP1572962.
JD502579 - Sequence 483603 from Patent EP1572962.
JD511069 - Sequence 492093 from Patent EP1572962.
JD088036 - Sequence 69060 from Patent EP1572962.
JD299781 - Sequence 280805 from Patent EP1572962.
JD566247 - Sequence 547271 from Patent EP1572962.
JD497236 - Sequence 478260 from Patent EP1572962.
JD036377 - Sequence 17401 from Patent EP1572962.
AK292401 - Homo sapiens cDNA FLJ77379 complete cds, highly similar to Homo sapiens zinc finger protein 482 (ZNF482), mRNA.
JD240221 - Sequence 221245 from Patent EP1572962.
JD310839 - Sequence 291863 from Patent EP1572962.
JD262817 - Sequence 243841 from Patent EP1572962.
JD256905 - Sequence 237929 from Patent EP1572962.
JD507392 - Sequence 488416 from Patent EP1572962.
JD450402 - Sequence 431426 from Patent EP1572962.
LF347070 - JP 2014500723-A/154573: Polycomb-Associated Non-Coding RNAs.
KJ893131 - Synthetic construct Homo sapiens clone ccsbBroadEn_02525 ZBTB6 gene, encodes complete protein.
EU446768 - Synthetic construct Homo sapiens clone IMAGE:100070262; IMAGE:100011977; FLH258218.01L zinc finger and BTB domain containing 6 (ZBTB6) gene, encodes complete protein.
AB464748 - Synthetic construct DNA, clone: pF1KB9672, Homo sapiens ZBTB6 gene for zinc finger and BTB domain containing protein 6, without stop codon, in Flexi system.
LF347071 - JP 2014500723-A/154574: Polycomb-Associated Non-Coding RNAs.
LF347072 - JP 2014500723-A/154575: Polycomb-Associated Non-Coding RNAs.
LF347073 - JP 2014500723-A/154576: Polycomb-Associated Non-Coding RNAs.
LF347074 - JP 2014500723-A/154577: Polycomb-Associated Non-Coding RNAs.
LF347078 - JP 2014500723-A/154581: Polycomb-Associated Non-Coding RNAs.
MA582645 - JP 2018138019-A/154571: Polycomb-Associated Non-Coding RNAs.
MA582646 - JP 2018138019-A/154572: Polycomb-Associated Non-Coding RNAs.
MA582647 - JP 2018138019-A/154573: Polycomb-Associated Non-Coding RNAs.
MA582648 - JP 2018138019-A/154574: Polycomb-Associated Non-Coding RNAs.
MA582649 - JP 2018138019-A/154575: Polycomb-Associated Non-Coding RNAs.
MA582650 - JP 2018138019-A/154576: Polycomb-Associated Non-Coding RNAs.
MA582651 - JP 2018138019-A/154577: Polycomb-Associated Non-Coding RNAs.
MA582655 - JP 2018138019-A/154581: Polycomb-Associated Non-Coding RNAs.
MA441257 - JP 2018138019-A/13183: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8N6, NM_006626, NP_006617, Q15916, uc004bnh.3, ZBTB6_HUMAN, ZID, ZNF482
UCSC ID: uc004bnh.4
RefSeq Accession: NM_006626
Protein: Q15916 (aka ZBTB6_HUMAN)
CCDS: CCDS6846.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006626.5
exon count: 2CDS single in 3' UTR: no RNA size: 4111
ORF size: 1275CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2750.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.