Human Gene GOLGA2 (uc004bum.1)
  Description: Homo sapiens golgin A2 (GOLGA2), mRNA.
RefSeq Summary (NM_004486): The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010].
Transcript (Including UTRs)
   Position: hg19 chr9:131,025,313-131,030,803 Size: 5,491 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr9:131,025,315-131,030,713 Size: 5,399 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:131,025,313-131,030,803)mRNA (may differ from genome)Protein (177 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMalacardsMGIPubMedUniProtKB
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GOLGA2
Diseases sorted by gene-association score: deafness, autosomal recessive 9 (7), mucopolysaccharidosis iii (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 65.97 RPKM in Pituitary
Total median expression: 1133.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.6090-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024858 - Golgin_A

ModBase Predicted Comparative 3D Structure on B7ZC05
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC069268 - Homo sapiens golgi autoantigen, golgin subfamily a, 2, mRNA (cDNA clone MGC:78452 IMAGE:6340972), complete cds.
BC006381 - Homo sapiens golgi autoantigen, golgin subfamily a, 2, mRNA (cDNA clone IMAGE:4099938), partial cds.
AF248953 - Homo sapiens golgi matrix protein GM130 (GOLGA2) mRNA, complete cds.
KJ901459 - Synthetic construct Homo sapiens clone ccsbBroadEn_10853 GOLGA2 gene, encodes complete protein.
AK075055 - Homo sapiens cDNA FLJ90574 fis, clone OVARC1001833.
AK129640 - Homo sapiens cDNA FLJ26129 fis, clone TMS02971.
CU686726 - Synthetic construct Homo sapiens gateway clone IMAGE:100023175 5' read GOLGA2 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZC05, B7ZC05_HUMAN, BC006381, RP11-395P17.5-009
UCSC ID: uc004bum.1
RefSeq Accession: NM_004486
Protein: B7ZC05

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC006381.2
exon count: 9CDS single in 3' UTR: no RNA size: 1885
ORF size: 531CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 1135.00frame shift in genome: no % Coverage: 31.03
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.