Description: Homo sapiens chromosome 9 open reading frame 142 (PAXX), mRNA. RefSeq Summary (NM_183241): The protein encoded by this gene plays a role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair. The encoded protein may function to stabilize the Ku70/Ku80 heterodimer to facilitate the assembly and maintain the stability of the NHEJ complex. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr9:139,886,870-139,888,428 Size: 1,559 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr9:139,886,896-139,888,257 Size: 1,362 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF15384 - PAXX, PAralog of XRCC4 and XLF, also called C9orf142
ModBase Predicted Comparative 3D Structure on Q9BUH6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0032947 protein complex scaffold GO:0042802 identical protein binding GO:0042803 protein homodimerization activity
Biological Process: GO:0006281 DNA repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0006974 cellular response to DNA damage stimulus GO:0051103 DNA ligation involved in DNA repair