Description: Homo sapiens RALBP1 associated Eps domain containing 2 (REPS2), transcript variant 2, mRNA. RefSeq Summary (NM_001080975): The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chrX:16,964,814-17,171,403 Size: 206,590 Total Exon Count: 18 Strand: + Coding Region Position: hg19 chrX:16,964,985-17,165,604 Size: 200,620 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF12763 - Cytoskeletal-regulatory complex EF hand
ModBase Predicted Comparative 3D Structure on Q8NFH8-4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.