Human Gene MAGEB10 (uc004dbw.3)
  Description: Homo sapiens melanoma antigen family B, 10 (MAGEB10), mRNA.
RefSeq Summary (NM_182506): This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Transcript (Including UTRs)
   Position: hg19 chrX:27,826,107-27,841,131 Size: 15,025 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chrX:27,839,424-27,840,467 Size: 1,044 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:27,826,107-27,841,131)mRNA (may differ from genome)Protein (347 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MAGBA_HUMAN
DESCRIPTION: RecName: Full=Melanoma-associated antigen B10; AltName: Full=MAGE-B10 antigen;
SIMILARITY: Contains 1 MAGE domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MAGEB10
Diseases sorted by gene-association score: melanoma (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.03 RPKM in Testis
Total median expression: 1.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.70245-0.354 Picture PostScript Text
3' UTR -196.22664-0.296 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002190 - MAGE
IPR021072 - Melanoma_ass_antigen_N

Pfam Domains:
PF01454 - MAGE family
PF12440 - Melanoma associated antigen family N terminal

ModBase Predicted Comparative 3D Structure on Q96LZ2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK057527 - Homo sapiens cDNA FLJ32965 fis, clone TESTI2008657, moderately similar to MELANOMA-ASSOCIATED ANTIGEN B4.
BC101307 - Homo sapiens melanoma antigen family B, 10, mRNA (cDNA clone MGC:120393 IMAGE:40024749), complete cds.
BC101309 - Homo sapiens melanoma antigen family B, 10, mRNA (cDNA clone MGC:120395 IMAGE:40024752), complete cds.
BC101310 - Homo sapiens melanoma antigen family B, 10, mRNA (cDNA clone MGC:120396 IMAGE:40024754), complete cds.
BC101308 - Homo sapiens melanoma antigen family B, 10, mRNA (cDNA clone MGC:120394 IMAGE:40024751), complete cds.
JD541346 - Sequence 522370 from Patent EP1572962.
JD071489 - Sequence 52513 from Patent EP1572962.
JD309686 - Sequence 290710 from Patent EP1572962.
JD068442 - Sequence 49466 from Patent EP1572962.
JD100795 - Sequence 81819 from Patent EP1572962.
JD099785 - Sequence 80809 from Patent EP1572962.
JD479940 - Sequence 460964 from Patent EP1572962.
AB463873 - Synthetic construct DNA, clone: pF1KB7150, Homo sapiens MAGEB10 gene for melanoma antigen family B, 10, without stop codon, in Flexi system.
KJ895534 - Synthetic construct Homo sapiens clone ccsbBroadEn_04928 MAGEB10 gene, encodes complete protein.
JD067338 - Sequence 48362 from Patent EP1572962.
JD530218 - Sequence 511242 from Patent EP1572962.
JD487170 - Sequence 468194 from Patent EP1572962.
JD511637 - Sequence 492661 from Patent EP1572962.
JD136300 - Sequence 117324 from Patent EP1572962.
JD243356 - Sequence 224380 from Patent EP1572962.
JD444773 - Sequence 425797 from Patent EP1572962.
JD177440 - Sequence 158464 from Patent EP1572962.
JD182545 - Sequence 163569 from Patent EP1572962.
JD512871 - Sequence 493895 from Patent EP1572962.
JD097719 - Sequence 78743 from Patent EP1572962.
JD100224 - Sequence 81248 from Patent EP1572962.
JD056691 - Sequence 37715 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: MAGBA_HUMAN, NM_182506, NP_872312, Q494Y6, Q494Y7, Q96LZ2, Q9BZ78
UCSC ID: uc004dbw.3
RefSeq Accession: NM_182506
Protein: Q96LZ2 (aka MAGBA_HUMAN)
CCDS: CCDS35221.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182506.3
exon count: 3CDS single in 3' UTR: no RNA size: 1953
ORF size: 1044CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2288.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.