Description: Homo sapiens polyglutamine binding protein 1 (PQBP1), transcript variant 8, mRNA. RefSeq Summary (NM_001167989): This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked cognitive disability. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]. Transcript (Including UTRs) Position: hg19 chrX:48,755,195-48,760,422 Size: 5,228 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chrX:48,755,793-48,760,361 Size: 4,569 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60828-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB016533 - Homo sapiens mRNA for nuclear protein containing a WW domain (Npw38), complete cds. BC012358 - Homo sapiens polyglutamine binding protein 1, mRNA (cDNA clone MGC:20443 IMAGE:4662649), complete cds. AJ242829 - Homo sapiens mRNA for PQBP-1 protein. AJ005893 - Homo sapiens mRNA for JM26 protein, complete CDS (clone LLOXNC01U138D3 (Baylor College)). AJ973604 - Homo sapiens partial mRNA for polyglutamine binding protein variant 12 (PQBP1 gene). AJ973605 - Homo sapiens mRNA for polyglutamine binding protein variant 13 (PQBP1 gene). AJ973593 - Homo sapiens mRNA for polyglutamine binding protein variant 1 (PQBP1 gene). AJ973594 - Homo sapiens mRNA for polyglutamine binding protein variant 2 (PQBP1 gene). AJ973595 - Homo sapiens mRNA for polyglutamine binding protein variant 3 (PQBP1 gene). AJ973596 - Homo sapiens mRNA for polyglutamine binding protein variant 4 (PQBP1 gene). AJ973597 - Homo sapiens mRNA for polyglutamine binding protein variant 5 (PQBP1 gene). AJ973598 - Homo sapiens mRNA for polyglutamine binding protein variant 6 (PQBP1 gene). AJ973599 - Homo sapiens mRNA for polyglutamine binding protein variant 7 (PQBP1 gene). AJ973600 - Homo sapiens mRNA for polyglutamine binding protein variant 8 (PQBP1 gene). AJ973602 - Homo sapiens mRNA for polyglutamine binding protein variant 10 (PQBP1 gene). AJ973603 - Homo sapiens mRNA for polyglutamine binding protein variant 11 (PQBP1 gene). AJ973606 - Homo sapiens mRNA for polyglutamine binding protein variant 14 (PQBP1 gene). AJ973607 - Homo sapiens mRNA for polyglutamine binding protein variant 15 (PQBP1 gene). AJ973601 - Homo sapiens mRNA for polyglutamine binding protein variant 9 (PQBP1 gene). CU680304 - Synthetic construct Homo sapiens gateway clone IMAGE:100023379 5' read PQBP1 mRNA. KJ892912 - Synthetic construct Homo sapiens clone ccsbBroadEn_02306 PQBP1 gene, encodes complete protein. KR710465 - Synthetic construct Homo sapiens clone CCSBHm_00013033 PQBP1 (PQBP1) mRNA, encodes complete protein. AB385557 - Synthetic construct DNA, clone: pF1KB8001, Homo sapiens PQBP1 gene for polyglutamine-binding protein 1, complete cds, without stop codon, in Flexi system. KU178500 - Homo sapiens polyglutamine binding protein 1 isoform 1 (PQBP1) mRNA, partial cds. KU178501 - Homo sapiens polyglutamine binding protein 1 isoform 2 (PQBP1) mRNA, partial cds, alternatively spliced. DQ892221 - Synthetic construct clone IMAGE:100004851; FLH184235.01X; RZPDo839D08144D polyglutamine binding protein 1 (PQBP1) gene, encodes complete protein. DQ894883 - Synthetic construct Homo sapiens clone IMAGE:100009343; FLH184231.01L; RZPDo839D08143D polyglutamine binding protein 1 (PQBP1) gene, encodes complete protein. AB041833 - Homo sapiens mRNA for PQBP-1a, complete cds. AB041834 - Homo sapiens mRNA for PQBP-1b/c, complete cds. AB041835 - Homo sapiens mRNA for PQBP-1b/c, complete cds. AB041836 - Homo sapiens mRNA for PQBP-1d, complete cds. JD548355 - Sequence 529379 from Patent EP1572962. JD074258 - Sequence 55282 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein O60828 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
