Description: Homo sapiens StAR-related lipid transfer (START) domain containing 8 (STARD8), transcript variant 2, mRNA. RefSeq Summary (NM_014725): This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]. Transcript (Including UTRs) Position: hg19 chrX:67,867,511-67,945,684 Size: 78,174 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chrX:67,936,217-67,944,264 Size: 8,048 Coding Exon Count: 11
ID:STAR8_HUMAN DESCRIPTION: RecName: Full=StAR-related lipid transfer protein 8; AltName: Full=Deleted in liver cancer 3 protein; Short=DLC-3; AltName: Full=START domain-containing protein 8; Short=StARD8; AltName: Full=START-GAP3; FUNCTION: Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1. SUBUNIT: Binds both the SH2 and PTB domains of TNS1. SUBCELLULAR LOCATION: Cell junction, focal adhesion. TISSUE SPECIFICITY: Widely expressed with highest levels in kidney, lung and placenta. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 START domain. SEQUENCE CAUTION: Sequence=BAA11506.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48350 - GTPase activation domain, GAP 55961 - Bet v1-like
ModBase Predicted Comparative 3D Structure on Q92502
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction