Human Gene STARD8 (uc004dxa.3)
  Description: Homo sapiens StAR-related lipid transfer (START) domain containing 8 (STARD8), transcript variant 2, mRNA.
RefSeq Summary (NM_014725): This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010].
Transcript (Including UTRs)
   Position: hg19 chrX:67,867,511-67,945,684 Size: 78,174 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chrX:67,936,217-67,944,264 Size: 8,048 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:67,867,511-67,945,684)mRNA (may differ from genome)Protein (1023 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDHuman Cortex Gene ExpressionLynx
MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: STAR8_HUMAN
DESCRIPTION: RecName: Full=StAR-related lipid transfer protein 8; AltName: Full=Deleted in liver cancer 3 protein; Short=DLC-3; AltName: Full=START domain-containing protein 8; Short=StARD8; AltName: Full=START-GAP3;
FUNCTION: Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1.
SUBUNIT: Binds both the SH2 and PTB domains of TNS1.
SUBCELLULAR LOCATION: Cell junction, focal adhesion.
TISSUE SPECIFICITY: Widely expressed with highest levels in kidney, lung and placenta.
SIMILARITY: Contains 1 Rho-GAP domain.
SIMILARITY: Contains 1 START domain.
SEQUENCE CAUTION: Sequence=BAA11506.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STARD8
CDC HuGE Published Literature: STARD8

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.12 RPKM in Lung
Total median expression: 198.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -168.80372-0.454 Picture PostScript Text
3' UTR -547.101420-0.385 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR023393 - START-like_dom
IPR002913 - START_lipid-bd

Pfam Domains:
PF00620 - RhoGAP domain
PF01852 - START domain

SCOP Domains:
48350 - GTPase activation domain, GAP
55961 - Bet v1-like

ModBase Predicted Comparative 3D Structure on Q92502
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity
GO:0008289 lipid binding

Biological Process:
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction

Cellular Component:
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  BC035587 - Homo sapiens StAR-related lipid transfer (START) domain containing 8, mRNA (cDNA clone MGC:45128 IMAGE:5518429), complete cds.
CR749411 - Homo sapiens mRNA; cDNA DKFZp686H1668 (from clone DKFZp686H1668).
JD185125 - Sequence 166149 from Patent EP1572962.
JD271897 - Sequence 252921 from Patent EP1572962.
JD253023 - Sequence 234047 from Patent EP1572962.
JD494564 - Sequence 475588 from Patent EP1572962.
JD495116 - Sequence 476140 from Patent EP1572962.
AK291747 - Homo sapiens cDNA FLJ77155 complete cds, highly similar to Homo sapiens START domain containing 8 (STARD8), mRNA.
D80011 - Homo sapiens mRNA for KIAA0189 gene.
KJ892841 - Synthetic construct Homo sapiens clone ccsbBroadEn_02235 STARD8 gene, encodes complete protein.
CU690122 - Synthetic construct Homo sapiens gateway clone IMAGE:100020479 5' read STARD8 mRNA.
AB384445 - Synthetic construct DNA, clone: pF1KA0189, Homo sapiens STARD8 gene for START domain-containing protein 8, complete cds, without stop codon, in Flexi system.
DQ890917 - Synthetic construct clone IMAGE:100003547; FLH167080.01X; RZPDo839H0388D START domain containing 8 (STARD8) gene, encodes complete protein.
JD451422 - Sequence 432446 from Patent EP1572962.
JD451382 - Sequence 432406 from Patent EP1572962.
JD460883 - Sequence 441907 from Patent EP1572962.
JD222075 - Sequence 203099 from Patent EP1572962.
JD136491 - Sequence 117515 from Patent EP1572962.
JD404289 - Sequence 385313 from Patent EP1572962.
JD047998 - Sequence 29022 from Patent EP1572962.
JD101619 - Sequence 82643 from Patent EP1572962.
JD371502 - Sequence 352526 from Patent EP1572962.
JD450592 - Sequence 431616 from Patent EP1572962.
JD447882 - Sequence 428906 from Patent EP1572962.
JD539695 - Sequence 520719 from Patent EP1572962.
JD469680 - Sequence 450704 from Patent EP1572962.
JD540026 - Sequence 521050 from Patent EP1572962.
JD297340 - Sequence 278364 from Patent EP1572962.
JD496759 - Sequence 477783 from Patent EP1572962.
JD166546 - Sequence 147570 from Patent EP1572962.
JD124224 - Sequence 105248 from Patent EP1572962.
JD116482 - Sequence 97506 from Patent EP1572962.
JD057001 - Sequence 38025 from Patent EP1572962.
JD457269 - Sequence 438293 from Patent EP1572962.
JD379342 - Sequence 360366 from Patent EP1572962.
JD137076 - Sequence 118100 from Patent EP1572962.
JD493613 - Sequence 474637 from Patent EP1572962.
JD159143 - Sequence 140167 from Patent EP1572962.
JD509957 - Sequence 490981 from Patent EP1572962.
JD292326 - Sequence 273350 from Patent EP1572962.
JD063678 - Sequence 44702 from Patent EP1572962.
JD445897 - Sequence 426921 from Patent EP1572962.
JD185770 - Sequence 166794 from Patent EP1572962.
JD449072 - Sequence 430096 from Patent EP1572962.
JD313874 - Sequence 294898 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q92502 (Reactome details) participates in the following event(s):

R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194840 Rho GTPase cycle
R-HSA-194315 Signaling by Rho GTPases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6T2, D3DVT9, DLC3, KIAA0189, NM_014725, NP_055540, Q5JST0, Q68DG7, Q92502, STAR8_HUMAN
UCSC ID: uc004dxa.3
RefSeq Accession: NM_014725
Protein: Q92502 (aka STAR8_HUMAN or STR8_HUMAN)
CCDS: CCDS14390.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014725.4
exon count: 14CDS single in 3' UTR: no RNA size: 4880
ORF size: 3072CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6023.00frame shift in genome: no % Coverage: 99.67
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.