Description: Homo sapiens tRNA methyltransferase 2 homolog B (S. cerevisiae) (TRMT2B), transcript variant 4, mRNA. RefSeq Summary (NM_001167972): This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]. Transcript (Including UTRs) Position: hg19 chrX:100,264,334-100,307,105 Size: 42,772 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chrX:100,265,570-100,292,986 Size: 27,417 Coding Exon Count: 10
ID:TRM2_HUMAN DESCRIPTION: RecName: Full=tRNA (uracil(54)-C(5))-methyltransferase homolog; EC=2.1.1.35; AltName: Full=TRM2 homolog; FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity). CATALYTIC ACTIVITY: S-adenosyl-L-methionine + uridine(54) in tRNA = S-adenosyl-L-homocysteine + 5-methyluridine(54) in tRNA. SIMILARITY: Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96GJ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
