Human Gene ARMCX4 (uc031tkc.1)
  Description: Homo sapiens armadillo repeat containing, X-linked 4 (ARMCX4), transcript variant 1, mRNA.
RefSeq Summary (NM_001256155): The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Transcript (Including UTRs)
   Position: hg19 chrX:100,743,031-100,750,798 Size: 7,768 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chrX:100,743,577-100,750,449 Size: 6,873 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:100,743,031-100,750,798)mRNA (may differ from genome)Protein (2290 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F8W8Y7_HUMAN
DESCRIPTION: SubName: Full=Armadillo repeat-containing X-linked protein 4;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.19 RPKM in Ovary
Total median expression: 140.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -71.40202-0.353 Picture PostScript Text
3' UTR -80.00349-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR006911 - ARM-rpt_dom
IPR016024 - ARM-type_fold
IPR000225 - Armadillo

Pfam Domains:
PF04826 - Armadillo-like

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on F8W8Y7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  CR933662 - Homo sapiens mRNA; cDNA DKFZp781M0415 (from clone DKFZp781M0415).
BC036206 - Homo sapiens armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5261888).
AK292543 - Homo sapiens cDNA FLJ77781 complete cds, highly similar to Homo sapiens armadillo repeat containing, X-linked 4 (ARMCX4), mRNA.
AK126987 - Homo sapiens cDNA FLJ45041 fis, clone BRAWH3020884, highly similar to Armadillo repeat-containing X-linked protein 4.
AK096955 - Homo sapiens cDNA FLJ39636 fis, clone SMINT2002976.
AK125041 - Homo sapiens cDNA FLJ43051 fis, clone BRTHA3005735.
BC032236 - Homo sapiens armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5246921).
KJ904357 - Synthetic construct Homo sapiens clone ccsbBroadEn_13751 ARMCX4 gene, encodes complete protein.
DQ581735 - Homo sapiens piRNA piR-49847, complete sequence.
AY726601 - Homo sapiens clone MO-32 mRNA sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: F8W8Y7, F8W8Y7_HUMAN, NM_001256155, NP_001243084, uc004eho.2
UCSC ID: uc031tkc.1
RefSeq Accession: NM_001256155
Protein: F8W8Y7 CCDS: CCDS59170.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001256155.1
exon count: 2CDS single in 3' UTR: no RNA size: 7424
ORF size: 6873CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 13497.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 6496# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.